Detailed information of TA system TA087041

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1465795..1466495
• Replicon: chromosome
• Accession: NZ_CP024173
• Organism: Bordetella bronchiseptica strain D987

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A0H3LPJ8
• Locus tag: CS345_RS06960
• Protein ID: WP_003809515.1
• Coordinates: 1465795..1466091 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: CS345_RS06965
• Protein ID: WP_003809516.1
• Coordinates: 1466094..1466495 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CS345_RS06940	1462092..1462634	+	543	WP_015064289.1	MOSC domain-containing protein	-
CS345_RS06945	1462810..1463874	+	1065	WP_015064288.1	fructose-bisphosphate aldolase class II	-
CS345_RS06950	1463959..1464405	-	447	WP_015064287.1	GFA family protein	-
CS345_RS06955	1464631..1465512	+	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
CS345_RS06960	1465795..1466091	+	297	WP_003809515.1	type II toxin-antitoxin system MqsR family toxin	Toxin
CS345_RS06965	1466094..1466495	+	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
CS345_RS06970	1466515..1466751	+	237	WP_003809519.1	hypothetical protein	-
CS345_RS06975	1466759..1467238	+	480	WP_003809523.1	disulfide bond formation protein B	-
CS345_RS06980	1467386..1467901	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
CS345_RS06985	1467904..1469094	+	1191	WP_003809527.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
CS345_RS06990	1469114..1470151	+	1038	WP_003809529.1	threonylcarbamoyl-AMP synthase	-
CS345_RS06995	1470288..1471322	+	1035	WP_015064286.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10608.50 Da
• Isoelectric Point: 7.9291

>T87041 WP_003809515.1 NZ_CP024173:1465795-1466091 [Bordetella bronchiseptica]
MEKGTPHCKLPALKALVHAGQVRATYSALSGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAV
YLKLTVLDGVLIVSFKEL

Nucleotide

• Length: 297 bp

>T87041 NZ_CP024173:1465795-1466091 [Bordetella bronchiseptica]
ATGGAAAAGGGAACACCGCACTGCAAGCTGCCGGCGCTCAAGGCGCTGGTCCATGCAGGCCAGGTCCGAGCCACGTATTC
CGCCTTGTCCGGCGCGGCGGCGCTGGGGCTGGATTTCAGCGCCATGGTCGAAATCGTGCTTGCACTGACACCGCGGGATT
TCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGGACGTCTATTGCCCAGTGACAGCGATGGGTGCCGTC
TACCTGAAGCTGACGGTCCTCGACGGCGTGCTGATCGTGTCGTTCAAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT87041 WP_003809516.1 NZ_CP024173:1466094-1466495 [Bordetella bronchiseptica]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT87041 NZ_CP024173:1466094-1466495 [Bordetella bronchiseptica]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACCATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCCGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGTTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCCCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Toxin

• AlphaFold DB: A0A0H3LPJ8

Antitoxin

• AlphaFold DB: A0A0H3LKS6