Detailed information of TA system TA087037

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1473331..1474031
• Replicon: chromosome
• Accession: NZ_CP024171
• Organism: Bordetella bronchiseptica strain D448

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A0H3LPJ8
• Locus tag: CS344_RS06980
• Protein ID: WP_003809515.1
• Coordinates: 1473331..1473627 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: CS344_RS06985
• Protein ID: WP_003809516.1
• Coordinates: 1473630..1474031 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CS344_RS06960	1469627..1470169	+	543	WP_010926149.1	molybdenum cofactor biosysynthesis protein	-
CS344_RS06965	1470345..1471409	+	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
CS344_RS06970	1471495..1471941	-	447	WP_003809511.1	GFA family protein	-
CS344_RS06975	1472167..1473048	+	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
CS344_RS06980	1473331..1473627	+	297	WP_003809515.1	type II toxin-antitoxin system MqsR family toxin	Toxin
CS344_RS06985	1473630..1474031	+	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
CS344_RS06990	1474051..1474287	+	237	WP_003809519.1	hypothetical protein	-
CS344_RS06995	1474295..1474774	+	480	WP_003809523.1	disulfide bond formation protein B	-
CS344_RS07000	1474922..1475437	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
CS344_RS07005	1475440..1476630	+	1191	WP_003809527.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
CS344_RS07010	1476650..1477687	+	1038	WP_003809529.1	threonylcarbamoyl-AMP synthase	-
CS344_RS07015	1477824..1478852	+	1029	WP_033447398.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10608.50 Da
• Isoelectric Point: 7.9291

>T87037 WP_003809515.1 NZ_CP024171:1473331-1473627 [Bordetella bronchiseptica]
MEKGTPHCKLPALKALVHAGQVRATYSALSGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAV
YLKLTVLDGVLIVSFKEL

Nucleotide

• Length: 297 bp

>T87037 NZ_CP024171:1473331-1473627 [Bordetella bronchiseptica]
ATGGAAAAGGGAACACCGCACTGCAAGCTGCCGGCGCTCAAGGCGCTGGTCCATGCAGGCCAGGTCCGAGCCACGTATTC
CGCCTTGTCCGGCGCGGCGGCGCTGGGGCTGGATTTCAGCGCCATGGTCGAAATCGTGCTTGCACTGACACCGCGGGATT
TCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGGACGTCTATTGCCCAGTGACAGCGATGGGTGCCGTC
TACCTGAAGCTGACGGTCCTCGACGGCGTGCTGATCGTGTCGTTCAAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT87037 WP_003809516.1 NZ_CP024171:1473630-1474031 [Bordetella bronchiseptica]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT87037 NZ_CP024171:1473630-1474031 [Bordetella bronchiseptica]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACCATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCCGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGTTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCCCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Toxin

• AlphaFold DB: A0A0H3LPJ8

Antitoxin

• AlphaFold DB: A0A0H3LKS6