Detailed information of TA system TA086868

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 274046..274268
• Replicon: chromosome
• Accession: NZ_CP024138
• Organism: Escherichia coli strain 14EC020

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: CR537_RS26975
• Protein ID: WP_001295224.1
• Coordinates: 274161..274268 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	274046..274104 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CR537_RS01395	269931..270935	+	1005	WP_000107036.1	dipeptide ABC transporter ATP-binding subunit DppF	-
CR537_RS01400	270965..272236	-	1272	WP_001318103.1	amino acid permease	-
CR537_RS26965	272712..272819	+	108	WP_000170738.1	type I toxin-antitoxin system toxin Ldr family protein	-
CR537_RS01420	273195..273302	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
CR537_RS26970	273678..273785	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	274046..274104	-	59	-	-	Antitoxin
CR537_RS26975	274161..274268	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
CR537_RS01440	274355..276034	-	1680	WP_001562264.1	cellulose biosynthesis protein BcsG	-
CR537_RS01445	276031..276222	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
CR537_RS01450	276219..277790	-	1572	WP_001204944.1	cellulose biosynthesis protein BcsE	-
CR537_RS01455	278063..278251	+	189	WP_001063315.1	YhjR family protein	-
CR537_RS01460	278263..279015	+	753	Protein_265	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T86868 WP_001295224.1 NZ_CP024138:274161-274268 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T86868 NZ_CP024138:274161-274268 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT86868 NZ_CP024138:c274104-274046 [Escherichia coli]
TCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin