Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2177480..2177999 Replicon chromosome
Accession NZ_CP024126
Organism Streptococcus suis strain HA0609

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0K2E7Z7
Locus tag CR542_RS11200 Protein ID WP_013730620.1
Coordinates 2177742..2177999 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag CR542_RS11195 Protein ID WP_002939010.1
Coordinates 2177480..2177740 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CR542_RS11155 2172666..2173025 + 360 WP_013730625.1 ribonuclease P protein component -
CR542_RS11160 2173009..2173821 + 813 WP_004194552.1 YidC/Oxa1 family membrane protein insertase -
CR542_RS11165 2173841..2174836 + 996 WP_013730624.1 protein jag -
CR542_RS11170 2175004..2175141 + 138 WP_002939016.1 50S ribosomal protein L34 -
CR542_RS11175 2175249..2176031 + 783 WP_099425962.1 TatD family hydrolase -
CR542_RS11180 2176015..2176584 + 570 WP_022540720.1 ribonuclease M5 -
CR542_RS11185 2176577..2176945 + 369 WP_013730622.1 hypothetical protein -
CR542_RS11190 2176949..2177404 + 456 WP_013730621.1 8-oxo-dGTP diphosphatase -
CR542_RS11195 2177480..2177740 + 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CR542_RS11200 2177742..2177999 + 258 WP_013730620.1 Txe/YoeB family addiction module toxin Toxin
CR542_RS11205 2178013..2178543 + 531 WP_009910909.1 DUF1697 domain-containing protein -
CR542_RS11210 2178527..2179435 + 909 WP_074411269.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
CR542_RS11215 2179798..2181528 + 1731 WP_009910905.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.86 Da        Isoelectric Point: 8.0279

>T86778 WP_013730620.1 NZ_CP024126:2177742-2177999 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

>T86778 NZ_CP024126:2177742-2177999 [Streptococcus suis]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCAAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCTCGGAGAATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT86778 WP_002939010.1 NZ_CP024126:2177480-2177740 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT86778 NZ_CP024126:2177480-2177740 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E7Z7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References