Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 3566759..3568457 Replicon chromosome
Accession NZ_CP024090
Organism Escherichia coli strain WG5

Toxin (Protein)


Gene name mosT Uniprot ID A0A3Y1KBU9
Locus tag CSR56_RS18150 Protein ID WP_047085429.1
Coordinates 3566759..3567688 (-) Length 310 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag CSR56_RS18155 Protein ID WP_172808160.1
Coordinates 3567675..3568457 (-) Length 261 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSR56_RS18120 3562187..3563695 + 1509 WP_032206693.1 group II intron reverse transcriptase/maturase -
CSR56_RS18125 3563785..3564258 + 474 Protein_3317 IS3 family transposase -
CSR56_RS18130 3564297..3564476 - 180 Protein_3318 hypothetical protein -
CSR56_RS18135 3564642..3565364 - 723 WP_081508859.1 SDR family oxidoreductase -
CSR56_RS18140 3565463..3566362 + 900 WP_000687182.1 LysR family transcriptional regulator -
CSR56_RS18150 3566759..3567688 - 930 WP_047085429.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
CSR56_RS18155 3567675..3568457 - 783 WP_172808160.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
CSR56_RS18160 3568741..3570405 + 1665 Protein_3323 DEAD/DEAH box helicase family protein -
CSR56_RS18165 3570471..3571633 + 1163 WP_085947598.1 IS3-like element IS3 family transposase -
CSR56_RS18170 3571663..3571998 - 336 Protein_3325 type III restriction endonuclease subunit R -
CSR56_RS18175 3572054..3572751 + 698 Protein_3326 IS1 family transposase -
CSR56_RS18185 3572768..3572971 - 204 Protein_3327 DUF3987 domain-containing protein -
CSR56_RS23810 3573030..3573125 + 96 WP_211180486.1 putative translational regulatory protein ArgL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3559029..3585644 26615


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-261)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(3-90)


Sequences

Toxin        


Download         Length: 310 a.a.        Molecular weight: 34960.38 Da        Isoelectric Point: 7.3232

>T86707 WP_047085429.1 NZ_CP024090:c3567688-3566759 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNSK
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMSVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKRNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVSKLERVLEQYS

Download         Length: 930 bp

>T86707 NZ_CP024090:c3567688-3566759 [Escherichia coli]
ATGGATCTGCGTGATAGCTATGCCAGGCAGGTTAAGCTGTTGATGGCTGCTCTGCCGCATGTGGCGAAGGAGTCCTGTTT
CGCGTTGAAAGGCGGCACGGCAATCAATTTGTTTGTGCAGGATTTTCCCCGTCTGTCGGTGGATATTGATCTGGCGTATA
AGAGCTTTGCGGATCGCGATACCGATCTGGCGGCTATCAACGACGCTTTGAAGAGAATTACTGCATCGCTGAACAGTAAA
CCGGGGATTACCGCGATCCGACAGGAAAATAAAGCGGATGAAAAGCGCATCATTGTGAATACCGCTGATGCAAAGATTAA
GATCGAGGTTAGCCCAGTCTGGCGCGGGCTGTTGTTGCCTCCGGCAGAAATGTCGGTGTGCGAACGTGTGGAAATGGAGT
ATGGTTTCACCACTATGAGTGTCGTTTCTCTGGCGGATCTTTATGGCGGTAAAATCTGCGCGGCGCTTGATCGTCAACAC
CCGCGCGATCTGTTTGATGTGCTGAATATGCTGGAGAAACCGGGACTGATGCGGGAGATCTTTGACGGTTTTCTTTGTTA
TCTGGCAGGCCATCCCCGTCCCATTGCCGAGTTGCTGGCTCCAAACTGGGATACAGATCGGATTGCCACGTTATACGCTC
AGGAATTTTCGGGGATGACTCAGCAGGAAACGTCGCTGGAATCGCTGCTGTCAGTAACGACTTTGCTGCCGCAGGCGTTG
AAGTCACATCTTACGGATCTGGATCGCGAGTTCTTGCTCAGTTTTAAGCGAAACAGCCCTGACTGGTCGCGGTATCGCTA
TCCTGAAATTCAGCATCTTCCGGCTATTCGCTGGAAGCAACGCAATCTGGCGGTGCTAAAAGATAAAAATCCTGCGAAGT
ATGTGGCGGCGGTGAGTAAGCTGGAGAGGGTTCTGGAGCAGTATTCTTAG

Antitoxin


Download         Length: 261 a.a.        Molecular weight: 29183.36 Da        Isoelectric Point: 8.5995

>AT86707 WP_172808160.1 NZ_CP024090:c3568457-3567675 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKSVRVAGLT
SLALQGHAHYTEPGRPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVTPFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGLNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGSGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Download         Length: 783 bp

>AT86707 NZ_CP024090:c3568457-3567675 [Escherichia coli]
TTGCCAAACTATCTAAACTGGTTGATGCAAAACACGCTACCCGGTCAGGTGCTGCTCCAGTCATGGCTTACCCGCAACGG
CGTAGATCGTAAGCTTTCTTATCTCTATGTTCAAAATGGCTGGCTCAGGCGCATCGCTCACGGCGTGTACTGCCGTACGG
GCCGTGAGCCGGATTGGGTAGACGCGGTTTACTGCCTGCAAACACAGTGGGAAAAGTCTGTTCGGGTGGCGGGGCTAACC
AGCCTTGCGCTACAGGGCCATGCGCACTATACCGAACCGGGCAGGCCGCAGGTCTGGCTCGCGCTTCCGGCTTACGTTAA
GCTGCCGGGATGGTTTGCTGCCTTCGAACAATCTGCAACATTTATCACGCTGTATACATCGGGCCTTACCGTTGATGTAA
CGCCATTTACCACGGAACTGAAAATTGGCGACCGCCAGTTAGCAGGCAGTGCCCCGGAACTGGCCGCGTATGAGATCGCC
TGCGGCGTTCCTTCGTTGATCTCGTTCGAACATGCCGATGCTCTGTTTCAGGGGTTGAATCTTCTCAGCCCACGCAAATT
GCAGGCACTGCTTCGCGCCAGTCATTCGATTAAAACCAACCGGGTGATGCTCTATCTTGCCCGGCGTAATGGACATCCTT
ATTTTCAGTATCTTGATCAAAGCGGTATAGAAACAGGTTCGGGAAAGCGGCAAATCATACCCGGTGGCTGGCTGGAGCCG
GATTATCAAATTACTGTTCCCCGCACATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Y1KBU9

Antitoxin

Source ID Structure

References