86675

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 357040..357673 Replicon chromosome
Accession NZ_CP024083
Organism Vibrio cholerae strain FORC_073

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag FORC73_RS16220 Protein ID WP_000843587.1
Coordinates 357040..357372 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FORC73_RS16225 Protein ID WP_000071008.1
Coordinates 357359..357673 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC73_RS16185 354623..355120 + 498 WP_000259910.1 GNAT family N-acetyltransferase -
FORC73_RS16195 355240..355521 + 282 WP_080033233.1 DUF1289 domain-containing protein -
FORC73_RS16210 355799..356083 - 285 WP_001963159.1 hypothetical protein -
FORC73_RS16215 356202..356789 - 588 WP_000130705.1 hypothetical protein -
FORC73_RS16220 357040..357372 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC73_RS16225 357359..357673 + 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin
FORC73_RS16235 357816..358334 + 519 WP_000698780.1 GNAT family N-acetyltransferase -
FORC73_RS16240 358479..359423 + 945 WP_086584918.1 restriction endonuclease -
FORC73_RS16245 359575..360072 + 498 WP_000259910.1 GNAT family N-acetyltransferase -
FORC73_RS16255 360192..360473 + 282 WP_119783490.1 DUF1289 domain-containing protein -
FORC73_RS16265 360852..361784 + 933 WP_001267735.1 hypothetical protein -
FORC73_RS16270 361768..362196 + 429 WP_119783491.1 hypothetical protein -
FORC73_RS16275 362414..362671 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 308518..372134 63616
- inside Integron - - 309195..371895 62700


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T86675 WP_000843587.1 NZ_CP024083:357040-357372 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T86675 NZ_CP024083:357040-357372 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGACGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT86675 WP_000071008.1 NZ_CP024083:357359-357673 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT86675 NZ_CP024083:357359-357673 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCACGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA

Antitoxin

Source ID Structure

References