Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 347818..348433 | Replicon | chromosome |
| Accession | NZ_CP024083 | ||
| Organism | Vibrio cholerae strain FORC_073 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMG5 |
| Locus tag | FORC73_RS16100 | Protein ID | WP_001162670.1 |
| Coordinates | 347818..348105 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | FORC73_RS16105 | Protein ID | WP_001232701.1 |
| Coordinates | 348116..348433 (+) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FORC73_RS16015 | 343032..343154 | + | 123 | WP_088132328.1 | DUF3265 domain-containing protein | - |
| FORC73_RS16020 | 343329..343456 | + | 128 | Protein_313 | DUF645 family protein | - |
| FORC73_RS16025 | 343472..343510 | + | 39 | WP_114763557.1 | hypothetical protein | - |
| FORC73_RS16030 | 343804..344282 | + | 479 | Protein_315 | DUF1456 family protein | - |
| FORC73_RS16040 | 344643..344753 | + | 111 | Protein_316 | DUF645 family protein | - |
| FORC73_RS16045 | 344901..345263 | + | 363 | WP_161418255.1 | DUF4144 domain-containing protein | - |
| FORC73_RS19300 | 345423..345755 | + | 333 | WP_055030569.1 | hypothetical protein | - |
| FORC73_RS16060 | 345879..346196 | - | 318 | WP_000077449.1 | CcdB family protein | - |
| FORC73_RS16065 | 346196..346441 | - | 246 | WP_001260801.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| FORC73_RS19305 | 346806..346977 | + | 172 | Protein_321 | DUF645 family protein | - |
| FORC73_RS16090 | 347094..347177 | + | 84 | WP_119783483.1 | iron transporter | - |
| FORC73_RS16095 | 347192..347587 | + | 396 | WP_000870868.1 | DUF3465 domain-containing protein | - |
| FORC73_RS16100 | 347818..348105 | + | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FORC73_RS16105 | 348116..348433 | + | 318 | WP_001232701.1 | HigA family addiction module antidote protein | Antitoxin |
| FORC73_RS19350 | 348430..348540 | + | 111 | WP_080308943.1 | DUF3265 domain-containing protein | - |
| FORC73_RS16115 | 348730..348908 | + | 179 | Protein_327 | DUF645 family protein | - |
| FORC73_RS19310 | 349272..349443 | + | 172 | Protein_328 | DUF645 family protein | - |
| FORC73_RS16140 | 350044..350601 | + | 558 | WP_119783487.1 | GNAT family N-acetyltransferase | - |
| FORC73_RS16150 | 350739..351080 | + | 342 | WP_000452085.1 | hypothetical protein | - |
| FORC73_RS16160 | 351362..352402 | - | 1041 | WP_032475915.1 | IS481 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 308518..372134 | 63616 | |
| - | inside | Integron | - | - | 309195..371895 | 62700 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11349.95 Da Isoelectric Point: 6.7187
>T86674 WP_001162670.1 NZ_CP024083:347818-348105 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
Download Length: 288 bp
>T86674 NZ_CP024083:347818-348105 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11705.63 Da Isoelectric Point: 10.4711
>AT86674 WP_001232701.1 NZ_CP024083:348116-348433 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
Download Length: 318 bp
>AT86674 NZ_CP024083:348116-348433 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGTGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTGAGTAATTTGATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGTGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTGAGTAATTTGATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|