Detailed information of TA system TA086564

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 6207307..6207842
• Replicon: chromosome
• Accession: NZ_CP023992
• Organism: Streptomyces malaysiensis strain DSM 4137

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: L1KUL2
• Locus tag: SMALA_RS25430
• Protein ID: WP_009321768.1
• Coordinates: 6207588..6207842 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: SMALA_RS25425
• Protein ID: WP_099014855.1
• Coordinates: 6207307..6207591 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMALA_RS25410	6203291..6203944	-	654	WP_107528525.1	winged helix-turn-helix domain-containing protein	-
SMALA_RS25415	6204059..6205402	-	1344	WP_099014854.1	recombinase	-
SMALA_RS25420	6205751..6206536	+	786	WP_069864458.1	hypothetical protein	-
SMALA_RS44345	6206824..6206988	+	165	WP_159033459.1	hypothetical protein	-
SMALA_RS25425	6207307..6207591	+	285	WP_099014855.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
SMALA_RS25430	6207588..6207842	+	255	WP_009321768.1	Txe/YoeB family addiction module toxin	Toxin
SMALA_RS25435	6208049..6208432	-	384	WP_099014856.1	hypothetical protein	-
SMALA_RS25440	6208981..6209763	-	783	WP_099014857.1	HAD family phosphatase	-
SMALA_RS25445	6209760..6210842	-	1083	WP_099014858.1	alcohol dehydrogenase catalytic domain-containing protein	-
SMALA_RS25450	6210955..6211878	+	924	WP_159033460.1	sugar nucleotide-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-65)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10098.61 Da
• Isoelectric Point: 8.4390

>T86564 WP_009321768.1 NZ_CP023992:6207588-6207842 [Streptomyces malaysiensis]
VRLVFEDQGWEDYTSWLKNDRKMLARINKLIEDVKRDPFTGIGKPEPLKYHLPGAWSRRIDDEHRLVYLVTDKEIVILAA
RYHY

Nucleotide

• Length: 255 bp

>T86564 NZ_CP023992:6207588-6207842 [Streptomyces malaysiensis]
GTGAGGCTTGTCTTCGAGGATCAGGGCTGGGAGGACTACACGTCCTGGCTCAAGAACGATCGCAAGATGCTGGCCCGGAT
CAATAAGCTCATCGAGGATGTCAAGCGCGACCCCTTCACGGGGATCGGCAAGCCTGAGCCGCTGAAGTACCACTTGCCCG
GAGCGTGGTCGAGGCGGATCGATGACGAGCACCGCCTTGTCTACTTGGTCACGGACAAGGAGATCGTGATCCTCGCGGCT
CGCTACCACTACTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10227.50 Da
• Isoelectric Point: 5.1514

>AT86564 WP_099014855.1 NZ_CP023992:6207307-6207591 [Streptomyces malaysiensis]
MSITASEARKALFPLIKKVNDDHEAIEIVSKHGNAVLVSAEDYAALREGSYLLRSPANARRLLKAYENALAHIDVSEREL
IDPDSPDAAGERAA

Nucleotide

• Length: 285 bp

>AT86564 NZ_CP023992:6207307-6207591 [Streptomyces malaysiensis]
ATGTCCATAACTGCGAGCGAAGCCCGCAAGGCTCTCTTTCCGCTGATCAAGAAGGTCAACGACGATCACGAGGCCATCGA
GATCGTCTCGAAGCACGGCAATGCCGTGCTCGTCTCGGCCGAGGACTATGCGGCATTGCGCGAAGGCTCGTACCTGCTGC
GCTCTCCGGCGAACGCTCGCCGACTGCTCAAAGCGTACGAGAACGCCCTGGCCCACATCGACGTGTCAGAGCGAGAGCTG
ATCGACCCCGACTCGCCGGATGCGGCCGGTGAGAGGGCTGCGTGA

Structures

Toxin

• AlphaFold DB: A0A540PPG9