Detailed information of TA system TA086545

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 4496688..4497342
• Replicon: chromosome
• Accession: NZ_CP023969
• Organism: Pseudomonas sp. FDAARGOS_380

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: CRN80_RS21195
• Protein ID: WP_003192123.1
• Coordinates: 4496992..4497342 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A5M8GG01
• Locus tag: CRN80_RS21190
• Protein ID: WP_032896658.1
• Coordinates: 4496688..4497002 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CRN80_RS21155	4492353..4493501	+	1149	WP_098950987.1	MFS transporter	-
CRN80_RS21160	4493498..4494019	-	522	WP_098952665.1	DUF3087 domain-containing protein	-
CRN80_RS21165	4494134..4494313	+	180	WP_003192131.1	hypothetical protein	-
CRN80_RS21170	4494326..4494526	+	201	WP_078467858.1	hypothetical protein	-
CRN80_RS21175	4494557..4494793	-	237	WP_003192128.1	hypothetical protein	-
CRN80_RS21180	4494914..4495747	+	834	WP_098950989.1	arylamine N-acetyltransferase	-
CRN80_RS21185	4495873..4496625	+	753	WP_003192126.1	outer membrane beta-barrel protein	-
CRN80_RS21190	4496688..4497002	-	315	WP_032896658.1	XRE family transcriptional regulator	Antitoxin
CRN80_RS21195	4496992..4497342	-	351	WP_003192123.1	toxin	Toxin
CRN80_RS21200	4497581..4499044	-	1464	WP_098950991.1	NADH-quinone oxidoreductase subunit NuoN	-
CRN80_RS21205	4499052..4500584	-	1533	WP_014718913.1	NADH-quinone oxidoreductase subunit M	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13826.71 Da
• Isoelectric Point: 9.7551

>T86545 WP_003192123.1 NZ_CP023969:c4497342-4496992 [Pseudomonas sp. FDAARGOS_380]
MDALFIELPAFERHRRDYLSDELFHGFQQELMKNPEAGDVIEGTGGLRKVRFVDERRNKGKRGGLRVIYYWWSGGTQFWL
FTLYGKHEQNDLTPQHKKALKHMLDREIKARTHHET

Nucleotide

• Length: 351 bp

>T86545 NZ_CP023969:c4497342-4496992 [Pseudomonas sp. FDAARGOS_380]
ATGGATGCTCTATTTATCGAACTGCCGGCATTCGAACGGCATCGCAGGGACTATCTGAGCGATGAGCTTTTTCACGGTTT
TCAGCAGGAGTTGATGAAAAACCCAGAAGCGGGAGACGTGATCGAAGGAACGGGCGGGTTGAGAAAGGTTCGCTTCGTCG
ATGAGCGACGAAACAAAGGCAAGCGCGGTGGCCTGCGGGTCATTTACTACTGGTGGTCAGGCGGTACGCAATTCTGGTTA
TTCACTTTGTACGGCAAACACGAACAGAACGACCTGACACCCCAACACAAGAAAGCCCTTAAACACATGCTAGACAGGGA
AATCAAAGCGAGAACACACCATGAAACGTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11797.66 Da
• Isoelectric Point: 10.9218

>AT86545 WP_032896658.1 NZ_CP023969:c4497002-4496688 [Pseudomonas sp. FDAARGOS_380]
MKREIFSELVEGFDALADERQGKITLRTHKAHLNKLAPLRAEEVIAVRQQLNLSRSVFAMYLRTNTRTLENWEQGRAKPN
AQAVTLIRLVARFPETVAQLAALG

Nucleotide

• Length: 315 bp

>AT86545 NZ_CP023969:c4497002-4496688 [Pseudomonas sp. FDAARGOS_380]
ATGAAACGTGAAATCTTTTCCGAACTGGTCGAAGGCTTCGACGCCCTGGCCGATGAACGCCAGGGCAAAATCACCCTGCG
CACCCACAAAGCGCACCTCAACAAGCTGGCGCCACTGCGCGCTGAGGAGGTAATCGCCGTACGCCAGCAACTCAACCTGT
CCCGCTCGGTATTCGCTATGTACCTGCGCACCAACACCCGCACCTTGGAGAACTGGGAGCAAGGCCGGGCCAAGCCGAAT
GCGCAGGCTGTCACTTTGATACGACTGGTGGCGCGCTTTCCGGAAACCGTGGCGCAACTTGCCGCATTGGGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A5M8GG01