Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1133176..1133678 Replicon chromosome
Accession NZ_CP023965
Organism Proteus vulgaris strain FDAARGOS_366

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag CRN77_RS05115 Protein ID WP_098941658.1
Coordinates 1133176..1133430 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag CRN77_RS05120 Protein ID WP_072068851.1
Coordinates 1133427..1133678 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRN77_RS05090 1128509..1129006 - 498 WP_098941654.1 Der GTPase-activating protein YihI -
CRN77_RS05095 1129195..1130667 + 1473 WP_098941655.1 glycosyltransferase family 39 protein -
CRN77_RS05100 1130670..1131218 + 549 WP_098941656.1 GNAT family N-acetyltransferase -
CRN77_RS05105 1131268..1131579 - 312 WP_098941657.1 monooxygenase -
CRN77_RS05110 1131660..1133018 - 1359 WP_075671246.1 NCS2 family permease -
CRN77_RS05115 1133176..1133430 - 255 WP_098941658.1 Txe/YoeB family addiction module toxin Toxin
CRN77_RS05120 1133427..1133678 - 252 WP_072068851.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
CRN77_RS05125 1133909..1134661 - 753 WP_098941659.1 amino acid ABC transporter permease -
CRN77_RS05130 1134663..1135400 - 738 WP_098941660.1 amino acid ABC transporter permease -
CRN77_RS05135 1135507..1136346 - 840 WP_036933789.1 ABC transporter substrate-binding protein -
CRN77_RS05140 1136561..1137295 - 735 WP_075671254.1 phosphate signaling complex protein PhoU -
CRN77_RS05145 1137310..1138086 - 777 WP_006534565.1 phosphate ABC transporter ATP-binding protein PstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10174.77 Da        Isoelectric Point: 9.9411

>T86534 WP_098941658.1 NZ_CP023965:c1133430-1133176 [Proteus vulgaris]
MKLIFSEQSWSDYLYWQQIDKKIIKRINELIKDIKRTTFSGIGKPEPLKHNLAGFWSRRITDEHRLIYRITDSAIEIASC
RYHY

Download         Length: 255 bp

>T86534 NZ_CP023965:c1133430-1133176 [Proteus vulgaris]
ATGAAATTAATTTTTTCTGAGCAATCATGGAGTGATTATCTTTATTGGCAACAAATAGACAAGAAAATAATTAAACGCAT
TAACGAACTCATAAAAGATATTAAAAGAACAACGTTTAGCGGAATAGGTAAACCAGAGCCCTTGAAACATAATTTAGCAG
GTTTTTGGTCAAGACGGATCACTGATGAACATCGCCTTATCTACCGTATTACTGATTCCGCTATAGAAATTGCATCATGT
CGATACCACTATTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9463.77 Da        Isoelectric Point: 4.4354

>AT86534 WP_072068851.1 NZ_CP023965:c1133678-1133427 [Proteus vulgaris]
MKTINYTEARQNLTSIMNETIDDRVPIMITRQKGIPCVLLSLDEYQALEETAYLLRSPANARHLLDSIDELNQGKGIEKD
ITE

Download         Length: 252 bp

>AT86534 NZ_CP023965:c1133678-1133427 [Proteus vulgaris]
ATGAAAACGATAAATTATACAGAAGCAAGACAAAACTTAACTTCAATTATGAATGAAACAATTGATGATAGAGTACCCAT
CATGATCACAAGGCAAAAGGGTATTCCATGTGTTCTTTTATCTCTTGATGAATACCAAGCACTAGAAGAAACTGCCTATC
TGTTACGATCTCCAGCGAATGCGCGCCATTTGCTCGATTCTATTGATGAACTGAACCAAGGTAAAGGTATAGAAAAGGAT
ATAACGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References