Detailed information of TA system TA086502

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/MqsA(antitoxin)
• Location: 2606836..2607507
• Replicon: chromosome
• Accession: NZ_CP023962
• Organism: Yersinia frederiksenii strain FDAARGOS_417

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0T9T807
• Locus tag: CRN74_RS12260
• Protein ID: WP_050080100.1
• Coordinates: 2607175..2607507 (-)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CRN74_RS12255
• Protein ID: WP_050080099.1
• Coordinates: 2606836..2607156 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CRN74_RS12240	2602908..2604608	+	1701	WP_050080096.1	sensor histidine kinase	-
CRN74_RS12245	2604612..2605352	+	741	WP_050287340.1	LytTR family DNA-binding domain-containing protein	-
CRN74_RS12250	2605566..2606810	+	1245	WP_050879349.1	OFA family MFS transporter	-
CRN74_RS12255	2606836..2607156	-	321	WP_050080099.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
CRN74_RS12260	2607175..2607507	-	333	WP_050080100.1	toxin	Toxin
CRN74_RS12265	2607664..2608635	-	972	WP_050287338.1	glucokinase	-
CRN74_RS12270	2608804..2609286	-	483	WP_050080102.1	multidrug/biocide efflux PACE transporter	-
CRN74_RS12275	2609388..2610272	+	885	WP_050080103.1	LysR family transcriptional regulator	-
CRN74_RS12280	2610247..2611905	-	1659	WP_186381613.1	indolepyruvate decarboxylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin MqsA/HigA-2 (35-99)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12914.87 Da
• Isoelectric Point: 10.1237

>T86502 WP_050080100.1 NZ_CP023962:c2607507-2607175 [Yersinia frederiksenii]
MDAVFIELPPFERVRLDYLSDDDYRTLQTALMNNPTVGDVIQQTGGLRKMRFSEAKTGKGKRSGVRVIYYWWVERFQFLL
FTIYSKGEMSDLTHSQRKILSNLLKSRKSE

Nucleotide

• Length: 333 bp

>T86502 NZ_CP023962:c2607507-2607175 [Yersinia frederiksenii]
ATGGATGCTGTATTTATTGAATTGCCACCATTTGAACGCGTTAGATTAGATTACTTATCAGACGATGATTATCGAACCTT
GCAGACTGCATTAATGAATAACCCAACGGTAGGAGATGTTATTCAACAAACTGGCGGTTTGCGCAAAATGCGATTCAGTG
AGGCGAAAACAGGGAAGGGCAAGCGTAGTGGTGTCAGAGTCATTTATTATTGGTGGGTCGAGCGTTTTCAGTTTTTGCTC
TTCACCATTTATAGCAAAGGTGAGATGTCTGACTTAACCCATTCGCAGCGGAAAATACTGAGTAATCTTCTTAAGTCCCG
TAAATCTGAATGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12162.92 Da
• Isoelectric Point: 8.5292

>AT86502 WP_050080099.1 NZ_CP023962:c2607156-2606836 [Yersinia frederiksenii]
MKKRDLFSELVEGMEAWGEANTGKKTLKTHKVSTENTVTLTSEELRHIRETLNISQALFAHYLQAGIATYQNWEQGRAKP
NKQAILLIKMVQKDPHTLHTLAELYE

Nucleotide

• Length: 321 bp

>AT86502 NZ_CP023962:c2607156-2606836 [Yersinia frederiksenii]
ATGAAAAAAAGAGATTTATTTTCAGAATTGGTTGAGGGAATGGAAGCGTGGGGAGAGGCAAATACGGGAAAGAAGACACT
GAAAACCCACAAAGTCTCGACTGAGAATACCGTGACCCTGACGTCAGAAGAATTACGGCACATCCGTGAAACACTGAATA
TTTCGCAGGCGCTATTTGCGCATTACTTGCAGGCGGGTATTGCAACTTACCAGAATTGGGAGCAAGGCCGAGCCAAACCC
AATAAGCAGGCTATCTTACTGATTAAAATGGTACAAAAAGATCCCCATACACTGCATACGCTCGCTGAACTGTACGAATG
A

Structures

Toxin

• AlphaFold DB: A0A0T9T807