Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 2606836..2607507 Replicon chromosome
Accession NZ_CP023962
Organism Yersinia frederiksenii strain FDAARGOS_417

Toxin (Protein)


Gene name higB Uniprot ID A0A0T9T807
Locus tag CRN74_RS12260 Protein ID WP_050080100.1
Coordinates 2607175..2607507 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CRN74_RS12255 Protein ID WP_050080099.1
Coordinates 2606836..2607156 (-) Length 107 a.a.

Genomic Context

CRN74_RS12240CRN74_RS12245CRN74_RS12250CRN74_RS12275CRN74_RS12255CRN74_RS12260CRN74_RS12265CRN74_RS12270CRN74_RS12280
Location: 2602908..2604608 (1701 bp)
Type: Others
Protein ID: WP_050080096.1
Location: 2604612..2605352 (741 bp)
Type: Others
Protein ID: WP_050287340.1
Location: 2605566..2606810 (1245 bp)
Type: Others
Protein ID: WP_050879349.1
Location: 2609388..2610272 (885 bp)
Type: Others
Protein ID: WP_050080103.1
Location: 2606836..2607156 (321 bp)
Type: Antitoxin
Protein ID: WP_050080099.1
Location: 2607175..2607507 (333 bp)
Type: Toxin
Protein ID: WP_050080100.1
Location: 2607664..2608635 (972 bp)
Type: Others
Protein ID: WP_050287338.1
Location: 2608804..2609286 (483 bp)
Type: Others
Protein ID: WP_050080102.1
Location: 2610247..2611905 (1659 bp)
Type: Others
Protein ID: WP_186381613.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CRN74_RS122402602908..2604608+1701WP_050080096.1sensor histidine kinase-
CRN74_RS122452604612..2605352+741WP_050287340.1LytTR family DNA-binding domain-containing protein-
CRN74_RS122502605566..2606810+1245WP_050879349.1OFA family MFS transporter-
CRN74_RS122552606836..2607156-321WP_050080099.1type II toxin-antitoxin system MqsA family antitoxinAntitoxin
CRN74_RS122602607175..2607507-333WP_050080100.1toxinToxin
CRN74_RS122652607664..2608635-972WP_050287338.1glucokinase-
CRN74_RS122702608804..2609286-483WP_050080102.1multidrug/biocide efflux PACE transporter-
CRN74_RS122752609388..2610272+885WP_050080103.1LysR family transcriptional regulator-
CRN74_RS122802610247..2611905-1659WP_186381613.1indolepyruvate decarboxylase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin MqsA/HigA-2

(35-99)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12914.87 Da        Isoelectric Point: 10.1237

>T86502 WP_050080100.1 NZ_CP023962:c2607507-2607175 [Yersinia frederiksenii]
MDAVFIELPPFERVRLDYLSDDDYRTLQTALMNNPTVGDVIQQTGGLRKMRFSEAKTGKGKRSGVRVIYYWWVERFQFLL
FTIYSKGEMSDLTHSQRKILSNLLKSRKSE

Download         Length: 333 bp

>T86502 NZ_CP023962:c2607507-2607175 [Yersinia frederiksenii]
ATGGATGCTGTATTTATTGAATTGCCACCATTTGAACGCGTTAGATTAGATTACTTATCAGACGATGATTATCGAACCTT
GCAGACTGCATTAATGAATAACCCAACGGTAGGAGATGTTATTCAACAAACTGGCGGTTTGCGCAAAATGCGATTCAGTG
AGGCGAAAACAGGGAAGGGCAAGCGTAGTGGTGTCAGAGTCATTTATTATTGGTGGGTCGAGCGTTTTCAGTTTTTGCTC
TTCACCATTTATAGCAAAGGTGAGATGTCTGACTTAACCCATTCGCAGCGGAAAATACTGAGTAATCTTCTTAAGTCCCG
TAAATCTGAATGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12162.92 Da        Isoelectric Point: 8.5292

>AT86502 WP_050080099.1 NZ_CP023962:c2607156-2606836 [Yersinia frederiksenii]
MKKRDLFSELVEGMEAWGEANTGKKTLKTHKVSTENTVTLTSEELRHIRETLNISQALFAHYLQAGIATYQNWEQGRAKP
NKQAILLIKMVQKDPHTLHTLAELYE

Download         Length: 321 bp

>AT86502 NZ_CP023962:c2607156-2606836 [Yersinia frederiksenii]
ATGAAAAAAAGAGATTTATTTTCAGAATTGGTTGAGGGAATGGAAGCGTGGGGAGAGGCAAATACGGGAAAGAAGACACT
GAAAACCCACAAAGTCTCGACTGAGAATACCGTGACCCTGACGTCAGAAGAATTACGGCACATCCGTGAAACACTGAATA
TTTCGCAGGCGCTATTTGCGCATTACTTGCAGGCGGGTATTGCAACTTACCAGAATTGGGAGCAAGGCCGAGCCAAACCC
AATAAGCAGGCTATCTTACTGATTAAAATGGTACAAAAAGATCCCCATACACTGCATACGCTCGCTGAACTGTACGAATG
A

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0T9T807

Antitoxin

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Source
ID
Structure
No matching records found

References