Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2179996..2181326 Replicon chromosome
Accession NZ_CP023962
Organism Yersinia frederiksenii strain FDAARGOS_417

Toxin (Protein)


Gene name HipT Uniprot ID A0A0T9T084
Locus tag CRN74_RS10150 Protein ID WP_050079782.1
Coordinates 2180304..2181326 (+) Length 341 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A0T9T098
Locus tag CRN74_RS10145 Protein ID WP_050079781.1
Coordinates 2179996..2180307 (+) Length 104 a.a.

Genomic Context

CRN74_RS10140CRN74_RS10145CRN74_RS10150CRN74_RS10130CRN74_RS10135CRN74_RS10155CRN74_RS10160CRN74_RS10165
Location: 2179667..2180011 (345 bp)
Type: Others
Protein ID: WP_050079780.1
Location: 2179996..2180307 (312 bp)
Type: Antitoxin
Protein ID: WP_050079781.1
Location: 2180304..2181326 (1023 bp)
Type: Toxin
Protein ID: WP_050079782.1
Location: 2177502..2178611 (1110 bp)
Type: Others
Protein ID: WP_050079778.1
Location: 2178686..2179300 (615 bp)
Type: Others
Protein ID: WP_050079779.1
Location: 2181534..2182316 (783 bp)
Type: Others
Protein ID: WP_098904702.1
Location: 2182548..2183522 (975 bp)
Type: Others
Protein ID: WP_098904703.1
Location: 2183690..2185114 (1425 bp)
Type: Others
Protein ID: WP_167311297.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CRN74_RS101302177502..2178611-1110WP_050079778.1efflux RND transporter periplasmic adaptor subunit-
CRN74_RS101352178686..2179300-615WP_050079779.1TetR/AcrR family transcriptional regulator-
CRN74_RS101402179667..2180011+345WP_050079780.1hypothetical protein-
CRN74_RS101452179996..2180307+312WP_050079781.1HipA N-terminal domain-containing proteinAntitoxin
CRN74_RS101502180304..2181326+1023WP_050079782.1HipA domain-containing proteinToxin
CRN74_RS101552181534..2182316-783WP_098904702.1SDR family oxidoreductase-
CRN74_RS101602182548..2183522-975WP_098904703.1chemotaxis protein-
CRN74_RS101652183690..2185114-1425WP_167311297.1EmmdR/YeeO family multidrug/toxin efflux MATE transporter-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(58-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 341 a.a.        Molecular weight: 38306.12 Da        Isoelectric Point: 6.9755

>T86501 WP_050079782.1 NZ_CP023962:2180304-2181326 [Yersinia frederiksenii]
MNPEHCLINLSRLKGAELKTGYSTKGIRHLFGRLEVALSLPFTRSQFIQELPERQKGMSISGYQPKLSLRLEGGELMVVS
NDGTYILKPSPEEYPHLAENEHATMCVMQRLKFEIPPFGLIAFKRDDNRSDELAFVIKRYDRLGADIMRLHQEQLDGAMG
LGDKYGNIDNKKAISYEKAAKFLNKSVSSSLKSMRDVFLRIVYAYILGNNDFHLRNFGIIHPEKGSSYLAPVYDFISVVP
YPTAFGEYLALPLLEREENDAASAPGLDSAYGEYLGADFILLAQGIGINPVLAKKWLTDVIKSHQLIIDTYTESHMPEAQ
REAVLKYVARRITLLAVTEL

Download         Length: 1023 bp

>T86501 NZ_CP023962:2180304-2181326 [Yersinia frederiksenii]
ATGAATCCAGAACACTGCCTGATAAATCTAAGCCGGCTTAAAGGAGCAGAGTTAAAAACGGGTTATTCAACAAAAGGGAT
TAGACATCTGTTTGGTCGCTTGGAAGTGGCCCTCAGCCTGCCTTTCACGCGAAGTCAGTTTATTCAGGAACTTCCTGAAC
GTCAGAAAGGGATGAGTATTTCAGGCTATCAACCTAAGTTATCTCTTCGCCTGGAGGGAGGGGAACTGATGGTCGTCAGC
AATGATGGTACCTATATCCTGAAACCCTCACCAGAAGAGTACCCACATCTGGCGGAAAACGAGCATGCGACAATGTGCGT
CATGCAACGTCTGAAATTTGAAATCCCGCCATTTGGACTGATAGCTTTCAAGCGCGACGATAACCGATCGGATGAATTGG
CTTTTGTGATCAAGAGGTATGACCGGCTGGGTGCAGATATAATGAGATTGCATCAAGAACAGTTGGATGGCGCGATGGGC
CTCGGCGATAAATATGGCAATATCGATAACAAGAAAGCCATCAGCTACGAGAAAGCCGCCAAATTCCTGAACAAGAGCGT
GAGTAGCAGCTTAAAGAGCATGCGTGACGTCTTTTTACGAATCGTCTATGCGTACATACTAGGCAATAATGATTTTCATC
TACGTAATTTCGGGATCATACACCCCGAAAAAGGTTCATCGTATCTGGCTCCTGTTTATGACTTTATCAGTGTTGTACCC
TACCCGACAGCTTTCGGAGAATATTTAGCTCTACCTCTCCTTGAGCGCGAGGAAAATGATGCAGCGAGCGCTCCGGGGCT
GGATTCAGCCTACGGGGAATACTTGGGCGCAGACTTTATCCTTCTCGCGCAGGGCATAGGTATTAATCCGGTTTTAGCCA
AAAAATGGCTTACTGACGTGATTAAGAGCCATCAGTTGATCATCGATACTTACACTGAAAGCCACATGCCAGAAGCGCAA
CGTGAAGCAGTGCTTAAGTACGTTGCACGGAGGATAACATTACTGGCAGTGACCGAACTTTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11748.64 Da        Isoelectric Point: 6.9762

>AT86501 WP_050079781.1 NZ_CP023962:2179996-2180307 [Yersinia frederiksenii]
MARKIGVWLYNKPVGTLSEEDIGFAFCYLANYTGRPISLSMPIRPEPYINQELHPFFKGLAPEGWLRKRYSEIQKIDDKD
LFGLLMQNGNDLLGAVVLKEITS

Download         Length: 312 bp

>AT86501 NZ_CP023962:2179996-2180307 [Yersinia frederiksenii]
ATGGCTCGAAAAATAGGTGTGTGGCTATACAACAAACCTGTAGGTACTTTGAGTGAAGAGGACATAGGTTTTGCCTTCTG
CTACCTAGCCAACTATACCGGCCGTCCTATATCGCTTAGCATGCCTATCAGGCCTGAACCTTATATTAATCAAGAACTTC
ATCCCTTCTTCAAAGGGTTGGCCCCAGAGGGTTGGCTGCGTAAACGATATTCTGAAATTCAAAAAATTGACGATAAGGAT
CTGTTCGGCTTACTGATGCAAAATGGTAACGACTTACTCGGGGCTGTAGTACTCAAAGAGATAACATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0T9T084

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0T9T098

References