86501

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2179996..2181326 Replicon chromosome
Accession NZ_CP023962
Organism Yersinia frederiksenii strain FDAARGOS_417

Toxin (Protein)


Gene name HipT Uniprot ID A0A0T9T084
Locus tag CRN74_RS10150 Protein ID WP_050079782.1
Coordinates 2180304..2181326 (+) Length 341 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A0T9T098
Locus tag CRN74_RS10145 Protein ID WP_050079781.1
Coordinates 2179996..2180307 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRN74_RS10130 2177502..2178611 - 1110 WP_050079778.1 efflux RND transporter periplasmic adaptor subunit -
CRN74_RS10135 2178686..2179300 - 615 WP_050079779.1 TetR/AcrR family transcriptional regulator -
CRN74_RS10140 2179667..2180011 + 345 WP_050079780.1 hypothetical protein -
CRN74_RS10145 2179996..2180307 + 312 WP_050079781.1 HipA N-terminal domain-containing protein Antitoxin
CRN74_RS10150 2180304..2181326 + 1023 WP_050079782.1 HipA domain-containing protein Toxin
CRN74_RS10155 2181534..2182316 - 783 WP_098904702.1 SDR family oxidoreductase -
CRN74_RS10160 2182548..2183522 - 975 WP_098904703.1 chemotaxis protein -
CRN74_RS10165 2183690..2185114 - 1425 WP_167311297.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(58-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 341 a.a.        Molecular weight: 38306.12 Da        Isoelectric Point: 6.9755

>T86501 WP_050079782.1 NZ_CP023962:2180304-2181326 [Yersinia frederiksenii]
MNPEHCLINLSRLKGAELKTGYSTKGIRHLFGRLEVALSLPFTRSQFIQELPERQKGMSISGYQPKLSLRLEGGELMVVS
NDGTYILKPSPEEYPHLAENEHATMCVMQRLKFEIPPFGLIAFKRDDNRSDELAFVIKRYDRLGADIMRLHQEQLDGAMG
LGDKYGNIDNKKAISYEKAAKFLNKSVSSSLKSMRDVFLRIVYAYILGNNDFHLRNFGIIHPEKGSSYLAPVYDFISVVP
YPTAFGEYLALPLLEREENDAASAPGLDSAYGEYLGADFILLAQGIGINPVLAKKWLTDVIKSHQLIIDTYTESHMPEAQ
REAVLKYVARRITLLAVTEL

Download         Length: 1023 bp

>T86501 NZ_CP023962:2180304-2181326 [Yersinia frederiksenii]
ATGAATCCAGAACACTGCCTGATAAATCTAAGCCGGCTTAAAGGAGCAGAGTTAAAAACGGGTTATTCAACAAAAGGGAT
TAGACATCTGTTTGGTCGCTTGGAAGTGGCCCTCAGCCTGCCTTTCACGCGAAGTCAGTTTATTCAGGAACTTCCTGAAC
GTCAGAAAGGGATGAGTATTTCAGGCTATCAACCTAAGTTATCTCTTCGCCTGGAGGGAGGGGAACTGATGGTCGTCAGC
AATGATGGTACCTATATCCTGAAACCCTCACCAGAAGAGTACCCACATCTGGCGGAAAACGAGCATGCGACAATGTGCGT
CATGCAACGTCTGAAATTTGAAATCCCGCCATTTGGACTGATAGCTTTCAAGCGCGACGATAACCGATCGGATGAATTGG
CTTTTGTGATCAAGAGGTATGACCGGCTGGGTGCAGATATAATGAGATTGCATCAAGAACAGTTGGATGGCGCGATGGGC
CTCGGCGATAAATATGGCAATATCGATAACAAGAAAGCCATCAGCTACGAGAAAGCCGCCAAATTCCTGAACAAGAGCGT
GAGTAGCAGCTTAAAGAGCATGCGTGACGTCTTTTTACGAATCGTCTATGCGTACATACTAGGCAATAATGATTTTCATC
TACGTAATTTCGGGATCATACACCCCGAAAAAGGTTCATCGTATCTGGCTCCTGTTTATGACTTTATCAGTGTTGTACCC
TACCCGACAGCTTTCGGAGAATATTTAGCTCTACCTCTCCTTGAGCGCGAGGAAAATGATGCAGCGAGCGCTCCGGGGCT
GGATTCAGCCTACGGGGAATACTTGGGCGCAGACTTTATCCTTCTCGCGCAGGGCATAGGTATTAATCCGGTTTTAGCCA
AAAAATGGCTTACTGACGTGATTAAGAGCCATCAGTTGATCATCGATACTTACACTGAAAGCCACATGCCAGAAGCGCAA
CGTGAAGCAGTGCTTAAGTACGTTGCACGGAGGATAACATTACTGGCAGTGACCGAACTTTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11748.64 Da        Isoelectric Point: 6.9762

>AT86501 WP_050079781.1 NZ_CP023962:2179996-2180307 [Yersinia frederiksenii]
MARKIGVWLYNKPVGTLSEEDIGFAFCYLANYTGRPISLSMPIRPEPYINQELHPFFKGLAPEGWLRKRYSEIQKIDDKD
LFGLLMQNGNDLLGAVVLKEITS

Download         Length: 312 bp

>AT86501 NZ_CP023962:2179996-2180307 [Yersinia frederiksenii]
ATGGCTCGAAAAATAGGTGTGTGGCTATACAACAAACCTGTAGGTACTTTGAGTGAAGAGGACATAGGTTTTGCCTTCTG
CTACCTAGCCAACTATACCGGCCGTCCTATATCGCTTAGCATGCCTATCAGGCCTGAACCTTATATTAATCAAGAACTTC
ATCCCTTCTTCAAAGGGTTGGCCCCAGAGGGTTGGCTGCGTAAACGATATTCTGAAATTCAAAAAATTGACGATAAGGAT
CTGTTCGGCTTACTGATGCAAAATGGTAACGACTTACTCGGGGCTGTAGTACTCAAAGAGATAACATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9T084

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9T098

References