Detailed information of TA system TA086320

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 651321..651579
• Replicon: chromosome
• Accession: NZ_CP023899
• Organism: Escherichia coli strain FDAARGOS_433

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: CRN16_RS04795
• Protein ID: WP_000809168.1
• Coordinates: 651427..651579 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	651321..651378 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CRN16_RS27630	646374..646940	+	567	WP_170950170.1	fimbria/pilus outer membrane usher protein	-
CRN16_RS27635	646915..647151	+	237	WP_170950167.1	fimbria/pilus outer membrane usher protein	-
CRN16_RS27640	647326..647700	+	375	WP_021521651.1	hypothetical protein	-
CRN16_RS27190	647713..648671	+	959	Protein_598	fimbrial family protein	-
CRN16_RS04785	648710..649609	-	900	WP_001300855.1	transcriptional activator NhaR	-
CRN16_RS04790	649675..650841	-	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
-	651321..651378	-	58	-	-	Antitoxin
CRN16_RS04795	651427..651579	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
CRN16_RS04800	651683..652813	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
CRN16_RS04805	652902..654818	-	1917	WP_000516131.1	molecular chaperone DnaK	-
CRN16_RS04810	655195..655599	+	405	WP_000843559.1	DUF2541 family protein	-
CRN16_RS04815	655625..656338	+	714	WP_001102383.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T86320 WP_000809168.1 NZ_CP023899:651427-651579 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T86320 NZ_CP023899:651427-651579 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT86320 NZ_CP023899:c651378-651321 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin