Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3624273..3624930 Replicon chromosome
Accession NZ_CP023775
Organism Burkholderia pseudomallei strain BPHN1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CNX72_RS18865 Protein ID WP_162946373.1
Coordinates 3624598..3624930 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CNX72_RS18860 Protein ID WP_120183666.1
Coordinates 3624273..3624605 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNX72_RS18840 3620026..3620670 - 645 WP_004195754.1 lytic polysaccharide monooxygenase -
CNX72_RS18845 3621183..3621500 - 318 WP_004266306.1 hypothetical protein -
CNX72_RS18850 3621717..3621941 + 225 WP_004195757.1 hypothetical protein -
CNX72_RS38110 3622283..3622744 - 462 WP_147483002.1 hypothetical protein -
CNX72_RS38115 3622728..3623282 - 555 WP_162946371.1 hypothetical protein -
CNX72_RS18855 3623282..3624088 - 807 WP_120183665.1 TIGR04255 family protein -
CNX72_RS18860 3624273..3624605 - 333 WP_120183666.1 helix-turn-helix domain-containing protein Antitoxin
CNX72_RS18865 3624598..3624930 - 333 WP_162946373.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CNX72_RS18870 3624972..3625559 - 588 WP_183157559.1 site-specific integrase -
CNX72_RS18875 3625927..3626706 - 780 WP_120183669.1 hypothetical protein -
CNX72_RS18880 3627221..3627454 + 234 WP_038726517.1 hypothetical protein -
CNX72_RS18885 3627468..3628814 - 1347 WP_038726519.1 type II secretory pathway protein -
CNX72_RS18890 3628811..3629737 - 927 WP_011852346.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(51-105)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12759.75 Da        Isoelectric Point: 10.3619

>T85995 WP_162946373.1 NZ_CP023775:c3624930-3624598 [Burkholderia pseudomallei]
MKQNWTVVYYNERVKRDVFALPAGILADYLRLLDLMQEFGADLRMPHSRAMGDGLFELRPKGREGIGRVFYCTHVGRHVV
VLHSFVKKTQETPQNELRTARTRLSEVRNG

Download         Length: 333 bp

>T85995 NZ_CP023775:c3624930-3624598 [Burkholderia pseudomallei]
ATGAAACAAAATTGGACAGTCGTCTACTACAACGAGCGTGTCAAGCGCGACGTCTTTGCGTTGCCGGCCGGGATCTTGGC
CGACTATCTCAGGCTGCTGGATTTGATGCAGGAGTTCGGCGCGGACCTGCGCATGCCGCATTCTCGGGCAATGGGGGACG
GATTGTTTGAGTTGCGCCCAAAGGGTAGGGAGGGTATCGGGCGTGTGTTCTACTGCACGCATGTGGGGCGGCATGTCGTT
GTGTTGCATTCGTTTGTGAAGAAAACGCAGGAAACTCCGCAGAATGAGCTGCGGACCGCCCGGACACGTTTGAGCGAGGT
ACGTAATGGCTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 11881.44 Da        Isoelectric Point: 8.9784

>AT85995 WP_120183666.1 NZ_CP023775:c3624605-3624273 [Burkholderia pseudomallei]
MAKVAATRERAEGFNPVPHTADDTERLLAKRGIKEAYDALDDEYSVLRAILAARQEAGLTQAQVAERMGTTASAVSRLEA
SLSSEKHSPSFATLRRYAAACGKRLVISFA

Download         Length: 333 bp

>AT85995 NZ_CP023775:c3624605-3624273 [Burkholderia pseudomallei]
ATGGCTAAGGTGGCAGCGACGCGCGAGCGTGCTGAGGGTTTTAATCCGGTTCCGCACACGGCGGATGATACAGAGCGCCT
GCTGGCAAAGCGTGGCATCAAAGAAGCTTATGACGCGCTGGATGATGAATACAGTGTGTTGCGGGCTATTCTGGCGGCCC
GGCAAGAGGCCGGCTTGACGCAAGCGCAGGTTGCTGAGCGCATGGGAACGACGGCCTCGGCTGTCTCCCGGCTTGAGGCG
TCGCTGTCGAGCGAAAAGCACTCTCCGTCGTTTGCAACGCTGCGTAGATATGCCGCAGCATGTGGAAAGAGGCTTGTGAT
CTCGTTTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References