Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 4020748..4021352 Replicon chromosome
Accession NZ_CP023737
Organism Methylosinus trichosporium OB3b

Toxin (Protein)


Gene name higB Uniprot ID A0A1A6FMI3
Locus tag CQW49_RS19020 Protein ID WP_003612979.1
Coordinates 4020748..4021065 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1A6FMG2
Locus tag CQW49_RS19025 Protein ID WP_003612976.1
Coordinates 4021062..4021352 (+) Length 97 a.a.

Genomic Context

CQW49_RS19020CQW49_RS19025CQW49_RS19040CQW49_RS19045CQW49_RS19050CQW49_RS19055CQW49_RS19060CQW49_RS19005CQW49_RS19010CQW49_RS19015CQW49_RS19030CQW49_RS19035
Location: 4020748..4021065 (318 bp)
Type: Toxin
Protein ID: WP_003612979.1
Location: 4021062..4021352 (291 bp)
Type: Antitoxin
Protein ID: WP_003612976.1
Location: 4022236..4022736 (501 bp)
Type: Others
Protein ID: WP_003612972.1
Location: 4022852..4024111 (1260 bp)
Type: Others
Protein ID: WP_003612971.1
Location: 4024320..4024835 (516 bp)
Type: Others
Protein ID: WP_024749488.1
Location: 4024959..4025453 (495 bp)
Type: Others
Protein ID: WP_003612966.1
Location: 4025743..4026030 (288 bp)
Type: Others
Protein ID: WP_024749487.1
Location: 4016373..4018178 (1806 bp)
Type: Others
Protein ID: WP_099831827.1
Location: 4018325..4019524 (1200 bp)
Type: Others
Protein ID: WP_003612982.1
Location: 4019601..4020563 (963 bp)
Type: Others
Protein ID: WP_003612980.1
Location: 4021383..4021793 (411 bp)
Type: Others
Protein ID: WP_003612974.1
Location: 4021793..4022080 (288 bp)
Type: Others
Protein ID: WP_003612973.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CQW49_RS190054016373..4018178-1806WP_099831827.1tetratricopeptide repeat protein-
CQW49_RS190104018325..4019524-1200WP_003612982.1ADP-forming succinate--CoA ligase subunit beta-
CQW49_RS190154019601..4020563-963WP_003612980.1malate dehydrogenase-
CQW49_RS190204020748..4021065+318WP_003612979.1type II toxin-antitoxin system RelE/ParE family toxinToxin
CQW49_RS190254021062..4021352+291WP_003612976.1helix-turn-helix transcriptional regulatorAntitoxin
CQW49_RS190304021383..4021793-411WP_003612974.1EVE domain-containing protein-
CQW49_RS190354021793..4022080-288WP_003612973.1YciI family protein-
CQW49_RS190404022236..4022736+501WP_003612972.1DUF2165 domain-containing protein-
CQW49_RS190454022852..4024111+1260WP_003612971.1c-type cytochrome-
CQW49_RS190504024320..4024835+516WP_024749488.1YchJ family protein-
CQW49_RS190554024959..4025453+495WP_003612966.1peptidoglycan-binding protein LysM-
CQW49_RS190604025743..4026030+288WP_024749487.1co-chaperone GroES-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-86)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12151.32 Da        Isoelectric Point: 10.9010

>T85983 WP_003612979.1 NZ_CP023737:4020748-4021065 [Methylosinus trichosporium OB3b]
MWSVEYLPAAAEEEAALPIEMQARLARMLDVIRRAGLTNLPRDWVKPLEGKLWELRITGKDGVARAIYVTAEGRRVVIVR
IFVKKTQKTPRRELELARRRAKEVE

Download         Length: 318 bp

>T85983 NZ_CP023737:4020748-4021065 [Methylosinus trichosporium OB3b]
ATGTGGTCTGTCGAATATCTGCCCGCTGCGGCCGAAGAGGAAGCGGCGCTTCCGATCGAGATGCAGGCGAGACTCGCCCG
GATGCTCGATGTCATCCGCCGTGCGGGGCTGACAAATTTGCCGCGCGACTGGGTGAAGCCGCTCGAGGGCAAATTGTGGG
AACTGCGGATCACCGGGAAGGACGGCGTCGCCCGCGCCATCTATGTCACAGCTGAAGGACGGCGCGTGGTCATCGTTCGA
ATCTTCGTGAAGAAGACGCAAAAAACGCCGCGGCGCGAGCTGGAGCTCGCTCGACGACGGGCGAAGGAGGTCGAATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10787.22 Da        Isoelectric Point: 9.5881

>AT85983 WP_003612976.1 NZ_CP023737:4021062-4021352 [Methylosinus trichosporium OB3b]
MTKTIDARIIHAKRMAEDEAYRAAYDALEEEFALVNSMIEARARSKLSQAEVAKRMGTTESAVSRLESGRGKPSTRTLER
YAEAVGHRLRITFEPS

Download         Length: 291 bp

>AT85983 NZ_CP023737:4021062-4021352 [Methylosinus trichosporium OB3b]
ATGACCAAGACGATCGACGCGCGAATCATTCATGCGAAGCGGATGGCCGAAGACGAGGCCTATCGCGCCGCCTATGACGC
GCTCGAAGAGGAGTTCGCTCTCGTCAATTCCATGATCGAGGCGCGAGCGCGTTCCAAATTGTCGCAGGCGGAAGTGGCGA
AGCGCATGGGCACGACGGAAAGCGCGGTGTCGAGGCTCGAATCCGGGCGCGGCAAACCATCGACGCGCACATTGGAACGC
TACGCCGAAGCCGTCGGGCATCGGCTGCGGATCACATTCGAGCCCTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1A6FMI3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1A6FMG2

References