Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | hok-sok/- |
Location | 55337..55590 | Replicon | plasmid unnamed3 |
Accession | NZ_CP023725 | ||
Organism | Klebsiella pneumoniae strain TVGHCRE225 |
Toxin (Protein)
Gene name | srnB | Uniprot ID | G9G1E3 |
Locus tag | CO233_RS31300 | Protein ID | WP_001312851.1 |
Coordinates | 55441..55590 (+) | Length | 50 a.a. |
Antitoxin (RNA)
Gene name | srnC | ||
Locus tag | - | ||
Coordinates | 55337..55396 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CO233_RS33300 | 50479..50940 | - | 462 | WP_014343465.1 | hypothetical protein | - |
CO233_RS31270 | 50897..51127 | + | 231 | WP_001261282.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
CO233_RS31275 | 51124..51540 | + | 417 | WP_001044770.1 | type II toxin-antitoxin system VapC family toxin | - |
CO233_RS31280 | 51614..53176 | + | 1563 | WP_004206609.1 | AAA family ATPase | - |
CO233_RS31285 | 53161..54183 | + | 1023 | WP_000361404.1 | helicase UvrD | - |
CO233_RS31290 | 54439..55136 | + | 698 | Protein_73 | IS1 family transposase | - |
- | 55337..55396 | - | 60 | NuclAT_0 | - | Antitoxin |
- | 55337..55396 | - | 60 | NuclAT_0 | - | Antitoxin |
- | 55337..55396 | - | 60 | NuclAT_0 | - | Antitoxin |
- | 55337..55396 | - | 60 | NuclAT_0 | - | Antitoxin |
CO233_RS31300 | 55441..55590 | + | 150 | WP_001312851.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
CO233_RS31305 | 55874..56122 | + | 249 | WP_000083837.1 | replication regulatory protein RepA | - |
CO233_RS31315 | 56367..56441 | + | 75 | WP_001375168.1 | RepA leader peptide Tap | - |
CO233_RS31320 | 56434..57291 | + | 858 | WP_032495102.1 | incFII family plasmid replication initiator RepA | - |
CO233_RS31330 | 58230..58883 | + | 654 | WP_000616807.1 | CPBP family intramembrane metalloprotease | - |
CO233_RS31820 | 58976..59233 | + | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
CO233_RS31335 | 59166..59567 | + | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
CO233_RS31350 | 59816..60231 | + | 416 | Protein_81 | IS1 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | blaKPC-2 | - | 1..103454 | 103454 | |
- | flank | IS/Tn | - | - | 54633..55136 | 503 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T85964 WP_001312851.1 NZ_CP023725:55441-55590 [Klebsiella pneumoniae]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T85964 NZ_CP023725:55441-55590 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 60 bp
>AT85964 NZ_CP023725:c55396-55337 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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