Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3408094..3408721 Replicon chromosome
Accession NZ_CP023706
Organism Edwardsiella tarda strain KC-Pc-HB1

Toxin (Protein)


Gene name higB Uniprot ID A0A411H7J1
Locus tag CPU03_RS15925 Protein ID WP_015871332.1
Coordinates 3408392..3408721 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CPU03_RS15920 Protein ID WP_005286394.1
Coordinates 3408094..3408402 (-) Length 103 a.a.

Genomic Context

CPU03_RS15895CPU03_RS15900CPU03_RS15905CPU03_RS15910CPU03_RS17470CPU03_RS17475CPU03_RS15930CPU03_RS15935CPU03_RS15940CPU03_RS17480CPU03_RS15945CPU03_RS15950CPU03_RS15915CPU03_RS15920CPU03_RS15925
Location: 3403868..3405250 (1383 bp)
Type: Others
Protein ID: WP_097364612.1
Location: 3405278..3405625 (348 bp)
Type: Others
Protein ID: WP_097364613.1
Location: 3405735..3406379 (645 bp)
Type: Others
Protein ID: WP_097364614.1
Location: 3406382..3406687 (306 bp)
Type: Others
Protein ID: WP_035603599.1
Location: 3406749..3407078 (330 bp)
Type: Others
Protein ID: WP_146196788.1
Location: 3407102..3407374 (273 bp)
Type: Others
Protein ID: WP_157757877.1
Location: 3409166..3409936 (771 bp)
Type: Others
Protein ID: WP_097364616.1
Location: 3410118..3411413 (1296 bp)
Type: Others
Protein ID: WP_157757878.1
Location: 3411535..3412353 (819 bp)
Type: Others
Protein ID: WP_097364618.1
Location: 3412587..3412985 (399 bp)
Type: Others
Protein ID: WP_157757879.1
Location: 3413102..3413332 (231 bp)
Type: Others
Protein ID: WP_015871327.1
Location: 3413307..3413636 (330 bp)
Type: Others
Protein ID: WP_035603613.1
Location: 3407487..3407999 (513 bp)
Type: Others
Protein ID: WP_097364615.1
Location: 3408094..3408402 (309 bp)
Type: Antitoxin
Protein ID: WP_005286394.1
Location: 3408392..3408721 (330 bp)
Type: Toxin
Protein ID: WP_015871332.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CPU03_RS158953403868..3405250+1383WP_097364612.1replicative DNA helicase-
CPU03_RS159003405278..3405625+348WP_097364613.1hypothetical protein-
CPU03_RS159053405735..3406379+645WP_097364614.1DUF1367 family protein-
CPU03_RS159103406382..3406687+306WP_035603599.1DUF1364 domain-containing protein-
CPU03_RS174703406749..3407078+330WP_146196788.1hypothetical protein-
CPU03_RS174753407102..3407374+273WP_157757877.1hypothetical protein-
CPU03_RS159153407487..3407999-513WP_097364615.1DUF2442 domain-containing protein-
CPU03_RS159203408094..3408402-309WP_005286394.1helix-turn-helix transcriptional regulatorAntitoxin
CPU03_RS159253408392..3408721-330WP_015871332.1type II toxin-antitoxin system RelE/ParE family toxinToxin
CPU03_RS159303409166..3409936+771WP_097364616.1Rha family transcriptional regulator-
CPU03_RS159353410118..3411413+1296WP_157757878.1hypothetical protein-
CPU03_RS159403411535..3412353+819WP_097364618.1hypothetical protein-
CPU03_RS174803412587..3412985+399WP_157757879.1hypothetical protein-
CPU03_RS159453413102..3413332+231WP_015871327.1ParD-like family protein-
CPU03_RS159503413307..3413636+330WP_035603613.1type II toxin-antitoxin system RelE/ParE family toxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--3376033..344731271279


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-97)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12771.78 Da        Isoelectric Point: 9.6247

>T85921 WP_015871332.1 NZ_CP023706:c3408721-3408392 [Edwardsiella tarda]
MNYTIEYYSEEVRLEVDQLPMGMRVRYQHLVERMEIYGSNLGEPHTSPFGDGLFELRIKGSDGIARVFYCTLTGKRIVML
HSFIKKTQKTPSAERKKAETRMKEVKHGW

Download         Length: 330 bp

>T85921 NZ_CP023706:c3408721-3408392 [Edwardsiella tarda]
ATGAACTACACTATTGAGTACTACAGCGAAGAGGTTCGGCTTGAGGTCGATCAGTTGCCAATGGGTATGCGGGTTCGATA
CCAGCATCTCGTTGAACGCATGGAAATCTACGGTAGTAATCTCGGAGAACCACACACAAGCCCTTTTGGCGATGGGCTTT
TTGAGCTTCGGATCAAAGGCAGTGATGGCATCGCCCGCGTGTTTTACTGCACTCTTACCGGAAAACGTATCGTCATGCTG
CACAGCTTCATCAAGAAAACCCAGAAGACGCCAAGCGCTGAACGTAAGAAGGCTGAAACCAGAATGAAGGAGGTAAAACA
TGGCTGGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11233.90 Da        Isoelectric Point: 8.5371

>AT85921 WP_005286394.1 NZ_CP023706:c3408402-3408094 [Edwardsiella tarda]
MAGKRTPPTMTHDEMAAKWMEDPAFKAEYDAIEEEYALLDEMLAARKNAGLTQAQVAERMGTKPTAITRMESNLASGQSG
PSFATLKKFAHATGKKLQIRFV

Download         Length: 309 bp

>AT85921 NZ_CP023706:c3408402-3408094 [Edwardsiella tarda]
ATGGCTGGTAAACGCACCCCCCCCACGATGACGCATGATGAAATGGCTGCAAAGTGGATGGAAGACCCGGCATTTAAAGC
AGAATACGATGCCATCGAAGAGGAATACGCCCTACTCGATGAAATGCTCGCCGCCCGCAAAAACGCGGGGCTGACCCAGG
CGCAGGTCGCCGAACGTATGGGAACCAAGCCTACAGCGATCACTCGCATGGAAAGTAATTTAGCCTCCGGCCAAAGCGGG
CCATCATTCGCCACGCTGAAAAAATTTGCACACGCGACCGGCAAGAAACTGCAGATCCGGTTTGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A411H7J1

Antitoxin

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Source
ID
Structure
No matching records found

References