Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 5149695..5150227 Replicon chromosome
Accession NZ_CP023703
Organism Streptomyces galilaeus strain ATCC 14969

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag CP966_RS23685 Protein ID WP_150472598.1
Coordinates 5149973..5150227 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag CP966_RS23680 Protein ID WP_150472597.1
Coordinates 5149695..5149976 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP966_RS23660 5145760..5146785 + 1026 WP_086764661.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
CP966_RS23665 5146815..5147564 + 750 WP_086764658.1 ROK family protein -
CP966_RS23670 5147643..5148143 - 501 WP_150474681.1 hypothetical protein -
CP966_RS23675 5148406..5149494 + 1089 WP_086764653.1 redox-regulated ATPase YchF -
CP966_RS23680 5149695..5149976 + 282 WP_150472597.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CP966_RS23685 5149973..5150227 + 255 WP_150472598.1 Txe/YoeB family addiction module toxin Toxin
CP966_RS23690 5150498..5152678 + 2181 WP_190046497.1 DEAD/DEAH box helicase -
CP966_RS23695 5152783..5153181 + 399 WP_150472599.1 hypothetical protein -
CP966_RS23700 5153381..5154604 + 1224 WP_150472600.1 DUF4190 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-64)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10084.58 Da        Isoelectric Point: 8.4390

>T85915 WP_150472598.1 NZ_CP023703:5149973-5150227 [Streptomyces galilaeus]
VRLVFEDQGWEDYTSWLKNDRKMLARINKLIEDVKRDPFTGIGKPEPLKYHLPGAWSRRIDDEHRLVYLVTDKEVIVLAA
RYHY

Download         Length: 255 bp

>T85915 NZ_CP023703:5149973-5150227 [Streptomyces galilaeus]
GTGAGGCTTGTCTTCGAGGATCAGGGCTGGGAGGACTACACGTCCTGGCTCAAGAACGACCGCAAGATGCTCGCTCGGAT
CAACAAGCTCATCGAGGACGTCAAGCGTGACCCCTTCACGGGGATCGGCAAGCCCGAGCCGCTCAAGTACCACTTGCCTG
GGGCGTGGTCGAGGCGGATCGATGACGAGCACCGACTCGTCTACCTGGTCACCGACAAAGAGGTCATCGTCCTCGCCGCT
CGCTACCACTACTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 9887.16 Da        Isoelectric Point: 5.6863

>AT85915 WP_150472597.1 NZ_CP023703:5149695-5149976 [Streptomyces galilaeus]
MSITASEARKALFPLIKKVNDDHEAIEIVSKHGNAVLVSAEDYAALREGSYLLRSPANARRLLKAYENALGNVNVSERAL
IDPDAADPAAGAA

Download         Length: 282 bp

>AT85915 NZ_CP023703:5149695-5149976 [Streptomyces galilaeus]
ATGTCCATAACTGCGAGCGAAGCCCGCAAGGCTCTCTTTCCGCTGATCAAGAAGGTCAACGACGATCACGAGGCCATCGA
GATCGTTTCCAAGCATGGCAACGCCGTGCTTGTCTCGGCCGAGGACTACGCGGCTCTGCGCGAGGGCTCGTACCTGCTGC
GTTCGCCCGCGAACGCGCGGCGGCTGCTCAAGGCGTACGAGAACGCCCTGGGCAATGTCAACGTGTCGGAGCGCGCACTG
ATCGATCCGGATGCGGCGGATCCCGCAGCGGGTGCCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References