Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 5068424..5068959 Replicon chromosome
Accession NZ_CP023697
Organism Streptomyces prasinus strain ATCC 13879

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1A5P7R1
Locus tag CP972_RS23010 Protein ID WP_055607560.1
Coordinates 5068705..5068959 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1A5P6Q1
Locus tag CP972_RS23005 Protein ID WP_055607559.1
Coordinates 5068424..5068708 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP972_RS22990 5063442..5064731 + 1290 WP_055607558.1 site-specific integrase -
CP972_RS34380 5065794..5067203 + 1410 WP_208817077.1 tyrosine-type recombinase/integrase -
CP972_RS23000 5067320..5067949 - 630 WP_055607563.1 class I SAM-dependent methyltransferase -
CP972_RS23005 5068424..5068708 + 285 WP_055607559.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CP972_RS23010 5068705..5068959 + 255 WP_055607560.1 Txe/YoeB family addiction module toxin Toxin
CP972_RS23015 5069012..5069308 - 297 WP_079060985.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CP972_RS23020 5069418..5071601 + 2184 WP_055607561.1 DEAD/DEAH box helicase -
CP972_RS23025 5072334..5073530 - 1197 WP_150475443.1 cytochrome P450 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-65)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10068.54 Da        Isoelectric Point: 8.4390

>T85912 WP_055607560.1 NZ_CP023697:5068705-5068959 [Streptomyces prasinus]
VRLVFEDQGWEDYTSWLKNDRKMPARINKLIEDVKRDPFTGLGKPEPLKYHLPGAWSRRIDDEHRLVYLVTDKEIVVLAA
RYHY

Download         Length: 255 bp

>T85912 NZ_CP023697:5068705-5068959 [Streptomyces prasinus]
GTGAGGCTCGTATTCGAGGATCAGGGCTGGGAGGACTACACGTCCTGGCTCAAGAACGACCGCAAGATGCCCGCTCGGAT
CAACAAGCTCATCGAGGACGTCAAACGCGACCCCTTCACCGGACTCGGTAAGCCCGAGCCGCTCAAGTACCACTTGCCAG
GTGCTTGGTCGCGGCGGATCGACGACGAGCACCGCCTGGTCTATCTGGTCACGGACAAGGAGATCGTGGTTCTCGCGGCC
CGCTATCACTACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10031.34 Da        Isoelectric Point: 6.4678

>AT85912 WP_055607559.1 NZ_CP023697:5068424-5068708 [Streptomyces prasinus]
MSITASEARKALFPLIKKVNDNHEAIEIVSKHGNAVLVSAEDYAALREGSYLLRSPANARRLLKAYENALAGINVSEREL
IDPDSPDAAGKGAG

Download         Length: 285 bp

>AT85912 NZ_CP023697:5068424-5068708 [Streptomyces prasinus]
ATGTCCATAACTGCGAGCGAAGCCCGCAAGGCTCTCTTTCCGCTGATCAAGAAGGTCAACGACAACCACGAGGCCATCGA
GATCGTTTCCAAGCACGGCAATGCCGTGCTCGTCTCGGCCGAGGACTATGCGGCACTGCGTGAGGGCTCGTACCTGCTGC
GCTCGCCGGCGAACGCTCGCCGGTTGCTCAAGGCGTACGAGAACGCCCTGGCCGGCATCAACGTGTCGGAGCGGGAGCTG
ATCGACCCCGACTCGCCGGATGCGGCCGGTAAGGGTGCCGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A5P7R1

Antitoxin

Source ID Structure
AlphaFold DB A0A1A5P6Q1

References