Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2976471..2977119 Replicon chromosome
Accession NZ_CP023612
Organism Mycobacterium tuberculosis strain LN2978

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag CP468_RS14525 Protein ID WP_003899414.1
Coordinates 2976471..2976794 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag CP468_RS14530 Protein ID WP_003899415.1
Coordinates 2976874..2977119 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP468_RS14505 2972045..2973306 + 1262 WP_096868035.1 IS3-like element IS987 family transposase -
CP468_RS14510 2973680..2975119 - 1440 WP_003899411.1 phage major capsid protein -
CP468_RS14515 2975127..2975660 - 534 WP_003899412.1 HK97 family phage prohead protease -
CP468_RS14520 2975813..2976304 - 492 WP_003900541.1 phage terminase small subunit P27 family -
CP468_RS14525 2976471..2976794 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
CP468_RS14530 2976874..2977119 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
CP468_RS14535 2977116..2978543 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
CP468_RS14540 2978545..2978937 - 393 WP_003899417.1 DUF2742 domain-containing protein -
CP468_RS14545 2978934..2979194 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
CP468_RS14550 2979211..2979573 - 363 WP_003900543.1 hypothetical protein -
CP468_RS14555 2979576..2980703 - 1128 WP_003899420.1 site-specific integrase -
CP468_RS14560 2980848..2981075 - 228 WP_003899421.1 hypothetical protein -
CP468_RS14565 2981072..2981461 - 390 WP_003899422.1 hypothetical protein -
CP468_RS14570 2981367..2981639 + 273 WP_003900544.1 hypothetical protein -
CP468_RS14575 2981738..2981971 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2970436..2980703 10267


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T84081 WP_003899414.1 NZ_CP023612:c2976794-2976471 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T84081 NZ_CP023612:c2976794-2976471 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT84081 WP_003899415.1 NZ_CP023612:c2977119-2976874 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT84081 NZ_CP023612:c2977119-2976874 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References