Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | unclassified/- |
Location | 2976328..2976976 | Replicon | chromosome |
Accession | NZ_CP023604 | ||
Organism | Mycobacterium tuberculosis strain LE76 |
Toxin (Protein)
Gene name | novel[antitoxin] | Uniprot ID | P9WJ12 |
Locus tag | CP460_RS14550 | Protein ID | WP_003899414.1 |
Coordinates | 2976328..2976651 (-) | Length | 108 a.a. |
Antitoxin (Protein)
Gene name | novel[toxin] | Uniprot ID | P9WJ10 |
Locus tag | CP460_RS14555 | Protein ID | WP_003899415.1 |
Coordinates | 2976731..2976976 (-) | Length | 82 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CP460_RS14530 | 2971902..2973163 | + | 1262 | WP_087902221.1 | IS3-like element IS987 family transposase | - |
CP460_RS14535 | 2973537..2974976 | - | 1440 | WP_003899411.1 | phage major capsid protein | - |
CP460_RS14540 | 2974984..2975517 | - | 534 | WP_003899412.1 | HK97 family phage prohead protease | - |
CP460_RS14545 | 2975670..2976161 | - | 492 | WP_003900541.1 | phage terminase small subunit P27 family | - |
CP460_RS14550 | 2976328..2976651 | - | 324 | WP_003899414.1 | type II toxin-antitoxin system toxin | Toxin |
CP460_RS14555 | 2976731..2976976 | - | 246 | WP_003899415.1 | type II toxin-antitoxin system antitoxin | Antitoxin |
CP460_RS14560 | 2976973..2978400 | - | 1428 | WP_003899416.1 | DUF3631 domain-containing protein | - |
CP460_RS14565 | 2978402..2978794 | - | 393 | WP_003899417.1 | DUF2742 domain-containing protein | - |
CP460_RS14570 | 2978791..2979051 | - | 261 | WP_003899418.1 | helix-turn-helix domain-containing protein | - |
CP460_RS14575 | 2979068..2979430 | - | 363 | WP_003900543.1 | hypothetical protein | - |
CP460_RS14580 | 2979433..2980560 | - | 1128 | WP_003899420.1 | site-specific integrase | - |
CP460_RS14585 | 2980705..2980932 | - | 228 | WP_003899421.1 | hypothetical protein | - |
CP460_RS14590 | 2980929..2981318 | - | 390 | WP_003899422.1 | hypothetical protein | - |
CP460_RS14595 | 2981224..2981496 | + | 273 | WP_003900544.1 | hypothetical protein | - |
CP460_RS14600 | 2981595..2981828 | + | 234 | WP_003413717.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | - | 2970293..2980560 | 10267 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 12359.82 Da Isoelectric Point: 8.6717
>T83594 WP_003899414.1 NZ_CP023604:c2976651-2976328 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ
Download Length: 324 bp
>T83594 NZ_CP023604:c2976651-2976328 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 7697.71 Da Isoelectric Point: 4.8565
>AT83594 WP_003899415.1 NZ_CP023604:c2976976-2976731 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P
Download Length: 246 bp
>AT83594 NZ_CP023604:c2976976-2976731 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A045IHC4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A806JR81 |