Detailed information of TA system TA083279

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2266552..2267471
• Replicon: chromosome
• Accession: NZ_CP023599
• Organism: Mycobacterium tuberculosis strain CSV383

Toxin (Protein)

• Gene name: HigB2
• Uniprot ID: -
• Locus tag: CP455_RS11035
• Protein ID: WP_024753682.1
• Coordinates: 2266866..2267471 (-)
• Length: 202 a.a.

Antitoxin (Protein)

• Gene name: HigA2
• Uniprot ID: L7N5K9
• Locus tag: CP455_RS11030
• Protein ID: WP_003410124.1
• Coordinates: 2266552..2266857 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CP455_RS10995	2261563..2262819	-	1257	WP_003902247.1	HNH endonuclease	-
CP455_RS11005	2263173..2263748	+	576	WP_003410100.1	hypothetical protein	-
CP455_RS11010	2263745..2264785	+	1041	WP_003410103.1	ImmA/IrrE family metallo-endopeptidase	-
CP455_RS11015	2265027..2265746	+	720	WP_003410108.1	DUF433 domain-containing protein	-
CP455_RS11020	2265736..2266152	+	417	WP_003410114.1	hypothetical protein	-
CP455_RS11025	2266168..2266467	-	300	WP_096863739.1	hypothetical protein	-
CP455_RS11030	2266552..2266857	-	306	WP_003410124.1	XRE family transcriptional regulator	Antitoxin
CP455_RS11035	2266866..2267471	-	606	WP_024753682.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CP455_RS11040	2267496..2267855	-	360	WP_003410131.1	hypothetical protein	-
CP455_RS11045	2268015..2268473	-	459	Protein_2088	hypothetical protein	-
CP455_RS11050	2268470..2269987	-	1518	Protein_2089	DEAD/DEAH box helicase	-
CP455_RS11055	2270497..2271495	-	999	WP_003410146.1	cation diffusion facilitator family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (86-181)

Antitoxin

• HigA2-like, helix-turn-helix domain (32-92)

Sequences

Toxin

Protein

• Length: 202 a.a.
• Molecular weight: 22743.97 Da
• Isoelectric Point: 7.6272

>T83279 WP_024753682.1 NZ_CP023599:c2267471-2266866 [Mycobacterium tuberculosis]
VNVPWENAHGGALYCLIRGNEFSAWHRLLFQRPGCAESVLACRHFLDGSPVARCSYPEEYHPCVISRIALLCDSVGWTAD
VERISAWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRSEVRILFAFDPARQAIMLAAG
NKAGRWTQWYDEKIKAADEMFAEHLAQFEDTKPKRRKRKKG

Nucleotide

• Length: 606 bp

>T83279 NZ_CP023599:c2267471-2266866 [Mycobacterium tuberculosis]
GTGAACGTTCCATGGGAGAACGCGCACGGCGGCGCACTGTACTGCCTCATACGTGGGAATGAATTCTCGGCCTGGCACAG
GCTACTGTTTCAACGGCCCGGGTGCGCAGAGTCCGTCCTCGCCTGCCGGCATTTCCTCGACGGTAGCCCCGTCGCCCGCT
GCTCTTACCCGGAGGAATATCACCCTTGTGTGATATCGCGTATCGCGCTACTCTGCGACTCTGTGGGGTGGACGGCGGAT
GTGGAGCGCATCTCCGCCTGGCTCAACGGCTTGGACCGAGAGACCTACGAATTGGTGTTCGCAGCTATCGAGGTTCTCGA
GGAAGAGGGCCCCGCACTTGGCTGTCCTCTGGTGGACACGGTGCGTGGGTCGCGCCACAAGAACATGAAGGAGCTGCGTC
CAGGATCACAAGGGCGGTCCGAGGTCCGCATTCTGTTCGCCTTCGACCCGGCGCGGCAGGCGATCATGCTGGCCGCCGGT
AACAAGGCCGGGCGGTGGACCCAGTGGTACGACGAGAAGATCAAAGCGGCCGATGAGATGTTTGCCGAACATCTCGCACA
GTTCGAGGACACGAAGCCAAAGAGGCGCAAGCGCAAGAAAGGGTAA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11291.91 Da
• Isoelectric Point: 10.7482

>AT83279 WP_003410124.1 NZ_CP023599:c2266857-2266552 [Mycobacterium tuberculosis]
MAMTLRDMDAVRPVNREAVDRHKARMRDEVRAFRLRELRAAQSLTQVQVAALAHIRQSRVSSIENGDIGSAQVNTLRKYV
SALGGELDITVRLGDETFTLA

Nucleotide

• Length: 306 bp

>AT83279 NZ_CP023599:c2266857-2266552 [Mycobacterium tuberculosis]
ATGGCGATGACACTACGGGACATGGACGCCGTACGTCCCGTTAACCGGGAGGCGGTGGACCGGCACAAGGCACGAATGCG
CGATGAAGTGCGGGCGTTCCGGCTCCGGGAGCTGCGCGCGGCTCAGTCACTCACCCAGGTCCAGGTGGCTGCGCTGGCGC
ACATCCGGCAGAGCCGGGTATCCAGCATCGAGAACGGCGACATCGGCTCCGCACAGGTCAACACACTGCGCAAATACGTG
TCCGCTCTTGGCGGAGAACTGGATATCACCGTCCGCCTGGGAGATGAGACATTCACCCTGGCATAG

Structures

Antitoxin

• AlphaFold DB: A0A7U4BV30