Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2976394..2977042 Replicon chromosome
Accession NZ_CP023574
Organism Mycobacterium tuberculosis strain CSV4644

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag CP430_RS14555 Protein ID WP_052635321.1
Coordinates 2976394..2976717 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag CP430_RS14560 Protein ID WP_003899415.1
Coordinates 2976797..2977042 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP430_RS14530 2971968..2973229 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
CP430_RS21915 2973256..2973441 - 186 WP_009935348.1 hypothetical protein -
CP430_RS14540 2973603..2975042 - 1440 WP_003899411.1 phage major capsid protein -
CP430_RS14545 2975050..2975583 - 534 WP_003899412.1 HK97 family phage prohead protease -
CP430_RS14550 2975736..2976227 - 492 WP_003900541.1 phage terminase small subunit P27 family -
CP430_RS14555 2976394..2976717 - 324 WP_052635321.1 type II toxin-antitoxin system toxin Toxin
CP430_RS14560 2976797..2977042 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
CP430_RS14565 2977039..2978466 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
CP430_RS14570 2978468..2978860 - 393 WP_003899417.1 DUF2742 domain-containing protein -
CP430_RS14575 2978857..2979117 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
CP430_RS14580 2979134..2979496 - 363 WP_003900543.1 hypothetical protein -
CP430_RS14585 2979499..2980626 - 1128 WP_003899420.1 site-specific integrase -
CP430_RS14590 2980771..2980998 - 228 WP_003899421.1 hypothetical protein -
CP430_RS14595 2980995..2981384 - 390 WP_003899422.1 hypothetical protein -
CP430_RS14600 2981290..2981562 + 273 WP_003900544.1 hypothetical protein -
CP430_RS14605 2981661..2981894 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2970359..2980626 10267


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(159-408)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-70)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12328.80 Da        Isoelectric Point: 8.6717

>T81771 WP_052635321.1 NZ_CP023574:c2976717-2976394 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRPHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T81771 NZ_CP023574:c2976717-2976394 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCC
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT81771 WP_003899415.1 NZ_CP023574:c2977042-2976797 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT81771 NZ_CP023574:c2977042-2976797 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References