81631

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1161285..1161855 Replicon chromosome
Accession NZ_CP023564
Organism Brachybacterium ginsengisoli strain DCY80

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CFK41_RS05080 Protein ID WP_096798691.1
Coordinates 1161285..1161566 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CFK41_RS05085 Protein ID WP_096798692.1
Coordinates 1161553..1161855 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFK41_RS05060 1157059..1158144 + 1086 WP_096798688.1 redox-regulated ATPase YchF -
CFK41_RS05065 1158447..1159382 - 936 WP_096800944.1 alpha/beta hydrolase -
CFK41_RS05070 1159499..1160086 + 588 WP_096798689.1 GNAT family N-acetyltransferase -
CFK41_RS05075 1160086..1160898 + 813 WP_096798690.1 PaaX family transcriptional regulator -
CFK41_RS05080 1161285..1161566 + 282 WP_096798691.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CFK41_RS05085 1161553..1161855 + 303 WP_096798692.1 HigA family addiction module antidote protein Antitoxin
CFK41_RS05090 1161852..1162346 + 495 WP_096798693.1 lincomycin resistance protein LmrB -
CFK41_RS05095 1162645..1163334 - 690 WP_096798694.1 TetR/AcrR family transcriptional regulator -
CFK41_RS05100 1163398..1164153 + 756 WP_076808296.1 SDR family oxidoreductase -
CFK41_RS05105 1164183..1164512 + 330 WP_076808295.1 nuclear transport factor 2 family protein -
CFK41_RS05110 1164615..1165781 + 1167 WP_076808293.1 low temperature requirement protein A -
CFK41_RS05115 1166105..1166385 + 281 Protein_1007 type II toxin-antitoxin system RelE/ParE family toxin -
CFK41_RS05120 1166360..1166683 + 324 WP_096798695.1 HigA family addiction module antidote protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11009.43 Da        Isoelectric Point: 10.5523

>T81631 WP_096798691.1 NZ_CP023564:1161285-1161566 [Brachybacterium ginsengisoli]
VIRSFGSKDTERLWRRERVRSIDHRIHRVALRKLRQVGSAESIEDLRVPPGNRLEALKGDRAGQHSIRINDEWRIWFVRT
DAGPEEVEIVDYH

Download         Length: 282 bp

>T81631 NZ_CP023564:1161285-1161566 [Brachybacterium ginsengisoli]
GTGATCAGATCGTTCGGGAGCAAGGACACCGAACGATTGTGGCGTCGTGAGCGAGTGCGCTCGATCGATCATCGGATCCA
TCGGGTCGCACTGCGCAAGCTTCGTCAGGTGGGATCGGCGGAGTCCATCGAGGATCTTCGGGTCCCGCCGGGCAACCGGC
TCGAAGCGCTGAAGGGCGACCGCGCCGGGCAGCACAGCATCAGGATCAACGACGAGTGGCGGATCTGGTTCGTGCGGACC
GACGCAGGACCGGAGGAGGTGGAGATCGTTGACTACCACTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11000.67 Da        Isoelectric Point: 4.7628

>AT81631 WP_096798692.1 NZ_CP023564:1161553-1161855 [Brachybacterium ginsengisoli]
MTTTEKIAPIHPGEVLMEDFIEGFGITQNKLAVSIGVPPRRINEIVHGKRGITADTALRLGKLFGTTAQFWLNLQTLYDL
DLAEDRVAEQIDAIVPLQSA

Download         Length: 303 bp

>AT81631 NZ_CP023564:1161553-1161855 [Brachybacterium ginsengisoli]
TTGACTACCACTGAGAAGATTGCCCCGATCCACCCTGGGGAGGTCCTCATGGAGGACTTCATCGAGGGCTTCGGGATCAC
GCAGAACAAGCTCGCCGTGTCGATCGGCGTCCCGCCTCGGCGGATCAACGAGATCGTGCATGGCAAGCGGGGGATCACGG
CGGACACCGCGCTCCGGCTCGGCAAGCTCTTCGGCACCACCGCACAGTTCTGGCTGAACCTGCAGACGCTCTACGACCTC
GACCTCGCAGAGGATCGCGTGGCTGAGCAGATCGACGCCATCGTGCCGCTGCAATCCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References