Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2491251..2491468 Replicon chromosome
Accession NZ_CP023561
Organism Staphylococcus aureus strain TF3198

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag CPC18_RS12890 Protein ID WP_001802298.1
Coordinates 2491364..2491468 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 2491251..2491306 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPC18_RS12870 2487389..2488054 - 666 WP_001024094.1 SDR family oxidoreductase -
CPC18_RS12875 2488206..2488526 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
CPC18_RS12880 2488528..2489508 + 981 WP_000019744.1 CDF family zinc efflux transporter CzrB -
CPC18_RS12885 2489774..2490864 + 1091 Protein_2389 transcriptional regulator -
- 2491251..2491306 + 56 - - Antitoxin
CPC18_RS12890 2491364..2491468 - 105 WP_001802298.1 hypothetical protein Toxin
CPC18_RS14640 2491629..2492112 - 484 Protein_2391 recombinase family protein -
CPC18_RS12900 2492155..2493291 - 1137 WP_000115564.1 SAP domain-containing protein -
CPC18_RS12905 2493580..2493672 + 93 WP_001790138.1 hypothetical protein -
CPC18_RS12910 2494377..2495234 - 858 WP_000370924.1 Cof-type HAD-IIB family hydrolase -
CPC18_RS12915 2495302..2496084 - 783 WP_000908177.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T81627 WP_001802298.1 NZ_CP023561:c2491468-2491364 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T81627 NZ_CP023561:c2491468-2491364 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 56 bp

>AT81627 NZ_CP023561:2491251-2491306 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References