Detailed information of TA system TA081627

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2491251..2491468
• Replicon: chromosome
• Accession: NZ_CP023561
• Organism: Staphylococcus aureus strain TF3198

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: CPC18_RS12890
• Protein ID: WP_001802298.1
• Coordinates: 2491364..2491468 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2491251..2491306 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CPC18_RS12870	2487389..2488054	-	666	WP_001024094.1	SDR family oxidoreductase	-
CPC18_RS12875	2488206..2488526	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
CPC18_RS12880	2488528..2489508	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
CPC18_RS12885	2489774..2490864	+	1091	Protein_2389	transcriptional regulator	-
-	2491251..2491306	+	56	-	-	Antitoxin
CPC18_RS12890	2491364..2491468	-	105	WP_001802298.1	hypothetical protein	Toxin
CPC18_RS14640	2491629..2492112	-	484	Protein_2391	recombinase family protein	-
CPC18_RS12900	2492155..2493291	-	1137	WP_000115564.1	SAP domain-containing protein	-
CPC18_RS12905	2493580..2493672	+	93	WP_001790138.1	hypothetical protein	-
CPC18_RS12910	2494377..2495234	-	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
CPC18_RS12915	2495302..2496084	-	783	WP_000908177.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T81627 WP_001802298.1 NZ_CP023561:c2491468-2491364 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T81627 NZ_CP023561:c2491468-2491364 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT81627 NZ_CP023561:2491251-2491306 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin