Detailed information of TA system TA081618

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2148318..2148500
• Replicon: chromosome
• Accession: NZ_CP023561
• Organism: Staphylococcus aureus strain TF3198

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: CPC18_RS10785
• Protein ID: WP_001801861.1
• Coordinates: 2148318..2148413 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2148441..2148500 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CPC18_RS10735	2143978..2144604	+	627	WP_000669046.1	hypothetical protein	-
CPC18_RS10740	2144645..2144989	+	345	WP_000627551.1	DUF3969 family protein	-
CPC18_RS10745	2145087..2145638	+	552	WP_000414205.1	hypothetical protein	-
CPC18_RS10750	2145856..2146497	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
CPC18_RS10755	2146611..2146796	-	186	WP_000809857.1	hypothetical protein	-
CPC18_RS10760	2146798..2146974	-	177	WP_000375476.1	hypothetical protein	-
CPC18_RS10765	2146985..2147368	-	384	WP_000070811.1	hypothetical protein	-
CPC18_RS10775	2147972..2148115	-	144	WP_001549059.1	transposase	-
CPC18_RS10785	2148318..2148413	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	2148441..2148500	-	60	-	-	Antitoxin
CPC18_RS10790	2148536..2148637	+	102	WP_001791893.1	hypothetical protein	-
CPC18_RS10795	2148615..2148791	-	177	Protein_2037	transposase	-
CPC18_RS10800	2148985..2149362	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2141418..2167015	25597

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T81618 WP_001801861.1 NZ_CP023561:2148318-2148413 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T81618 NZ_CP023561:2148318-2148413 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 60 bp

>AT81618 NZ_CP023561:c2148500-2148441 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin