Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 8840..9024 Replicon chromosome
Accession NZ_CP023561
Organism Staphylococcus aureus strain TF3198

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag CPC18_RS00055 Protein ID WP_000482650.1
Coordinates 8917..9024 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 8840..8900 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPC18_RS00030 4370..4537 - 168 WP_001790576.1 hypothetical protein -
CPC18_RS00040 4768..6501 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
CPC18_RS00045 6526..8289 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 8840..8900 + 61 - - Antitoxin
CPC18_RS00055 8917..9024 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
CPC18_RS00060 9157..9543 - 387 WP_000779358.1 flippase GtxA -
CPC18_RS00065 9811..10953 + 1143 WP_001176863.1 glycerate kinase -
CPC18_RS00070 11013..11672 + 660 WP_000831298.1 membrane protein -
CPC18_RS00075 11854..13065 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
CPC18_RS00080 13188..13661 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T81613 WP_000482650.1 NZ_CP023561:c9024-8917 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T81613 NZ_CP023561:c9024-8917 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT81613 NZ_CP023561:8840-8900 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References