Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4229193..4229734 Replicon chromosome
Accession NZ_CP023535
Organism Escherichia coli strain FDAARGOS_403

Toxin (Protein)


Gene name yafQ Uniprot ID B7LHF6
Locus tag CO706_RS23475 Protein ID WP_000615974.1
Coordinates 4229193..4229471 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag CO706_RS23480 Protein ID WP_000729704.1
Coordinates 4229474..4229734 (-) Length 87 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO706_RS23460 4226775..4227353 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
CO706_RS23465 4227559..4228326 + 768 WP_000333380.1 class II glutamine amidotransferase -
CO706_RS23470 4228297..4229037 - 741 WP_001225679.1 murein L,D-transpeptidase -
CO706_RS23475 4229193..4229471 - 279 WP_000615974.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
CO706_RS23480 4229474..4229734 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
CO706_RS23485 4229920..4230693 + 774 WP_000543895.1 C40 family peptidase -
CO706_RS23490 4230750..4231106 - 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
CO706_RS23495 4231099..4231377 - 279 WP_000598758.1 type II toxin-antitoxin system HicA family toxin -
CO706_RS23500 4231482..4233194 - 1713 Protein_4034 flagellar biosynthesis protein FlhA -
CO706_RS23505 4233166..4233951 + 786 WP_000207574.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10855.68 Da        Isoelectric Point: 10.2267

>T81570 WP_000615974.1 NZ_CP023535:c4229471-4229193 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMRLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T81570 NZ_CP023535:c4229471-4229193 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGAGGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT81570 WP_000729704.1 NZ_CP023535:c4229734-4229474 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT81570 NZ_CP023535:c4229734-4229474 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0E0Y514


Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References