Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3947288..3948053 Replicon chromosome
Accession NZ_CP023525
Organism Cedecea neteri strain FDAARGOS_392

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CO704_RS18850 Protein ID WP_061279158.1
Coordinates 3947745..3948053 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CO704_RS18845 Protein ID WP_096754209.1
Coordinates 3947288..3947629 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO704_RS18825 3943502..3944613 + 1112 WP_096753957.1 IS3 family transposase -
CO704_RS18830 3944877..3945368 - 492 WP_038475281.1 TIGR00645 family protein -
CO704_RS18835 3945431..3945856 - 426 WP_081948173.1 phosphate-starvation-inducible protein PsiE -
CO704_RS18840 3946518..3946994 - 477 WP_061279161.1 WbuC family cupin fold metalloprotein -
CO704_RS18845 3947288..3947629 - 342 WP_096754209.1 HigA family addiction module antidote protein Antitoxin
CO704_RS18850 3947745..3948053 - 309 WP_061279158.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CO704_RS18855 3948339..3949486 + 1148 WP_096753947.1 IS3 family transposase -
CO704_RS18860 3949625..3950536 - 912 WP_061278877.1 hypothetical protein -
CO704_RS18865 3951759..3952256 - 498 WP_061278868.1 carboxypeptidase regulatory-like domain-containing protein -
CO704_RS18870 3952318..3952959 - 642 WP_061278866.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3934526..3964939 30413
- inside IScluster/Tn - - 3943502..3949486 5984


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-70)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 12012.65 Da        Isoelectric Point: 9.3654

>T81482 WP_061279158.1 NZ_CP023525:c3948053-3947745 [Cedecea neteri]
VLESIGSFRDKWLEEFFDTGKSHAKIPADIESVLARKLDIINAAVDFRDLRSPPGNRFENLESPLQEYSSIRVNDKYRIL
FKWVNGKAEQVYFEPHKYKKHK

Download         Length: 309 bp

>T81482 NZ_CP023525:c3948053-3947745 [Cedecea neteri]
GTGTTAGAAAGCATTGGAAGCTTTCGTGACAAATGGCTGGAGGAATTCTTTGATACAGGAAAGTCTCACGCCAAAATCCC
GGCAGACATTGAGTCTGTTTTGGCTCGAAAGCTCGACATAATAAACGCGGCGGTGGATTTTCGGGACTTGCGCTCACCAC
CTGGTAACAGGTTCGAAAACTTAGAGTCACCATTACAAGAGTATTCGTCTATCAGAGTTAATGATAAGTATCGGATACTC
TTCAAATGGGTTAACGGCAAGGCTGAACAAGTCTACTTCGAGCCGCATAAGTACAAAAAACATAAGTAG

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12958.87 Da        Isoelectric Point: 6.2269

>AT81482 WP_096754209.1 NZ_CP023525:c3947629-3947288 [Cedecea neteri]
IHQAMRKPTTVGDVLLYEYLEPLGLKINDLAEMLLVHRNTVSALVNNNRKLTIDMALRLSKIFNTTVKFWLNIQQNVDVW
EAMNDARTQEELGRLKPVSLATSEQDSHERDVA

Download         Length: 342 bp

>AT81482 NZ_CP023525:c3947629-3947288 [Cedecea neteri]
ATTCATCAAGCCATGAGGAAACCAACTACAGTCGGAGATGTACTACTGTATGAATACCTGGAGCCTTTGGGTCTTAAAAT
TAATGACTTGGCAGAAATGTTGTTAGTACACCGCAACACTGTCAGCGCACTGGTGAACAATAACCGAAAACTTACCATCG
ACATGGCGCTTCGCCTGTCTAAAATTTTTAATACCACTGTCAAATTCTGGCTGAACATTCAGCAGAACGTTGATGTATGG
GAAGCAATGAATGACGCCCGCACTCAGGAGGAACTGGGCCGGTTGAAGCCTGTCTCCCTTGCAACAAGCGAACAAGACAG
CCACGAACGTGACGTTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References