Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3752694..3753236 Replicon chromosome
Accession NZ_CP023525
Organism Cedecea neteri strain FDAARGOS_392

Toxin (Protein)


Gene name yafQ Uniprot ID A0A291E1C4
Locus tag CO704_RS17960 Protein ID WP_061275468.1
Coordinates 3752694..3752975 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A291E1N8
Locus tag CO704_RS17965 Protein ID WP_061275466.1
Coordinates 3752979..3753236 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO704_RS17950 3748179..3751433 - 3255 WP_061275472.1 type I-F CRISPR-associated helicase Cas3 -
CO704_RS17955 3751430..3752401 - 972 WP_096754153.1 type I-F CRISPR-associated endonuclease Cas1 -
CO704_RS17960 3752694..3752975 - 282 WP_061275468.1 type II toxin-antitoxin system YafQ family toxin Toxin
CO704_RS17965 3752979..3753236 - 258 WP_061275466.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CO704_RS17970 3753914..3754822 - 909 WP_061275513.1 LysR family transcriptional regulator -
CO704_RS17975 3754979..3755374 + 396 WP_061275464.1 cupin domain-containing protein -
CO704_RS17980 3755388..3756128 + 741 WP_061275462.1 SDR family oxidoreductase -
CO704_RS17985 3756346..3758001 + 1656 WP_061275460.1 L-lactate permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3743289..3753236 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-82)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10913.68 Da        Isoelectric Point: 9.5745

>T81481 WP_061275468.1 NZ_CP023525:c3752975-3752694 [Cedecea neteri]
MPQREISYTGQFKRDLRLAQKRGCDIPKLQGIMMQMMNDQFPLPAALLDHPLTGNYKKHRELHVEPDWLLIYKISNTELQ
FVRTGSHSDLFKS

Download         Length: 282 bp

>T81481 NZ_CP023525:c3752975-3752694 [Cedecea neteri]
ATGCCCCAAAGGGAGATCAGTTACACCGGACAGTTTAAGCGTGATTTGAGGTTGGCCCAAAAAAGAGGATGCGATATCCC
AAAGCTGCAGGGCATCATGATGCAGATGATGAATGACCAGTTCCCATTACCTGCAGCCTTGTTAGACCATCCTCTGACTG
GGAATTACAAAAAACACAGGGAATTGCATGTTGAGCCTGACTGGCTCCTGATTTATAAGATTTCCAATACTGAACTGCAG
TTTGTCAGAACAGGCTCACATTCGGATTTATTCAAAAGCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9455.92 Da        Isoelectric Point: 4.5994

>AT81481 WP_061275466.1 NZ_CP023525:c3753236-3752979 [Cedecea neteri]
MSINAVVRARIDPAIRDEATEVLAQFGMTISDVMRMTLAYVAKERALPFEMRLNATTIETIEKAEAGIEVHRASDAKDLF
DQLGM

Download         Length: 258 bp

>AT81481 NZ_CP023525:c3753236-3752979 [Cedecea neteri]
ATGAGTATCAATGCCGTGGTACGTGCCCGGATTGACCCTGCTATTCGTGATGAGGCTACAGAAGTATTGGCTCAGTTTGG
CATGACCATAAGTGACGTTATGCGGATGACCTTAGCGTATGTCGCTAAAGAGCGCGCATTGCCTTTCGAAATGCGCCTGA
ATGCAACGACTATCGAGACGATTGAAAAGGCCGAGGCGGGAATAGAGGTTCATCGCGCTAGTGATGCCAAAGATTTGTTC
GACCAACTGGGGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291E1C4

Antitoxin

Source ID Structure
AlphaFold DB A0A291E1N8

References