Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1643080..1643741 Replicon chromosome
Accession NZ_CP023525
Organism Cedecea neteri strain FDAARGOS_392

Toxin (Protein)


Gene name higB Uniprot ID A0A291DW09
Locus tag CO704_RS07765 Protein ID WP_061276686.1
Coordinates 1643080..1643454 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A291DWN8
Locus tag CO704_RS07770 Protein ID WP_061276688.1
Coordinates 1643439..1643741 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO704_RS07745 1638657..1639715 + 1059 WP_061276681.1 FUSC family protein -
CO704_RS07750 1639889..1640224 + 336 WP_038481379.1 DUF496 family protein -
CO704_RS07755 1640263..1640571 - 309 WP_061276683.1 helix-turn-helix domain-containing protein -
CO704_RS07760 1640762..1642864 + 2103 WP_061276684.1 elongation factor G -
CO704_RS07765 1643080..1643454 + 375 WP_061276686.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CO704_RS07770 1643439..1643741 + 303 WP_061276688.1 XRE family transcriptional regulator Antitoxin
CO704_RS07775 1643789..1644163 - 375 WP_061276689.1 hypothetical protein -
CO704_RS07780 1644167..1645543 - 1377 WP_061276690.1 MFS transporter -
CO704_RS07785 1645654..1646553 + 900 WP_061276692.1 LysR family transcriptional regulator -
CO704_RS07790 1646571..1648097 - 1527 WP_061276694.1 cytosine permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14343.78 Da        Isoelectric Point: 8.7141

>T81471 WP_061276686.1 NZ_CP023525:1643080-1643454 [Cedecea neteri]
MWSIKMTDTFDAWIMASDDITKACVMAAVVLLKERGPLLGRPYADTVKGSQYANMKELRIQRKGDPLRIFFAFDIRRCAI
LLCAGNKVGNEKRFYDVMVPLADNEFRAHLKQLSEKEQIEWVER

Download         Length: 375 bp

>T81471 NZ_CP023525:1643080-1643454 [Cedecea neteri]
ATGTGGTCGATAAAAATGACGGATACGTTTGATGCGTGGATCATGGCATCAGATGACATCACTAAAGCCTGTGTTATGGC
GGCGGTAGTATTACTGAAAGAGAGAGGTCCTTTGCTCGGTAGACCTTATGCTGACACGGTGAAAGGGTCACAATACGCAA
ATATGAAAGAACTGCGTATCCAGCGCAAAGGTGATCCACTCAGGATCTTTTTTGCTTTTGATATCAGGCGCTGCGCCATC
CTGCTCTGTGCGGGGAATAAAGTGGGCAATGAGAAGCGATTTTATGACGTTATGGTGCCCTTAGCGGACAACGAATTTCG
AGCACACTTAAAGCAATTATCGGAAAAGGAGCAAATAGAATGGGTCGAACGCTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11215.05 Da        Isoelectric Point: 8.5893

>AT81471 WP_061276688.1 NZ_CP023525:1643439-1643741 [Cedecea neteri]
MGRTLEQWMAQEKPEVVAAAQAMADEMLLNIHLAELRDRVRKTQNEMAQKLGVKQPTVAEMEKKGRDIKLSSLKRYVEAA
GGKVQLDVELPDGSHFKIAL

Download         Length: 303 bp

>AT81471 NZ_CP023525:1643439-1643741 [Cedecea neteri]
ATGGGTCGAACGCTAGAACAATGGATGGCTCAGGAGAAACCCGAAGTGGTGGCCGCAGCGCAGGCCATGGCCGATGAGAT
GCTGCTGAATATCCACCTCGCTGAATTGCGCGATCGGGTAAGGAAAACGCAGAACGAGATGGCGCAAAAGCTGGGTGTGA
AGCAGCCGACCGTTGCCGAAATGGAAAAAAAAGGCCGTGATATCAAGCTATCTTCGCTCAAACGCTATGTTGAAGCGGCG
GGCGGCAAGGTTCAGCTGGATGTTGAACTGCCGGACGGCTCCCATTTTAAAATTGCGCTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291DW09

Antitoxin

Source ID Structure
AlphaFold DB A0A291DWN8

References