Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1559440..1560085 Replicon chromosome
Accession NZ_CP023525
Organism Cedecea neteri strain FDAARGOS_392

Toxin (Protein)


Gene name higB Uniprot ID A0A291DVU3
Locus tag CO704_RS07390 Protein ID WP_061276559.1
Coordinates 1559440..1559805 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A291DWC2
Locus tag CO704_RS07395 Protein ID WP_061276561.1
Coordinates 1559789..1560085 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO704_RS07380 1554794..1557916 - 3123 WP_061276555.1 MdtB/MuxB family multidrug efflux RND transporter permease subunit -
CO704_RS07385 1557916..1559169 - 1254 WP_061276557.1 MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit -
CO704_RS07390 1559440..1559805 + 366 WP_061276559.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CO704_RS07395 1559789..1560085 + 297 WP_061276561.1 helix-turn-helix transcriptional regulator Antitoxin
CO704_RS07400 1560137..1561489 - 1353 WP_061276564.1 molecular chaperone -
CO704_RS07405 1561651..1562496 + 846 WP_061276567.1 DNA-3-methyladenine glycosylase 2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14314.39 Da        Isoelectric Point: 9.5930

>T81470 WP_061276559.1 NZ_CP023525:1559440-1559805 [Cedecea neteri]
MTWTVIFTDYFYFWYQAQPLDLRKRLAAAFGNLEFWGPELSRPQADTVKGSRYPNMKELRLLWRGKPYRIFFAFDPRRRA
VVLCGGDKSGNKRFYEALIKVADTQLAHHLADLESEYENLN

Download         Length: 366 bp

>T81470 NZ_CP023525:1559440-1559805 [Cedecea neteri]
ATGACATGGACCGTAATTTTTACCGACTATTTCTATTTTTGGTATCAGGCGCAGCCTTTGGATCTTCGCAAACGGCTTGC
GGCAGCCTTCGGAAATCTTGAGTTCTGGGGGCCTGAGTTGAGCCGTCCGCAGGCTGATACAGTAAAAGGCTCCCGCTATC
CTAATATGAAAGAGCTACGCCTGCTGTGGCGGGGGAAGCCGTATCGAATATTTTTTGCTTTTGATCCAAGGCGCAGGGCC
GTTGTGCTGTGCGGTGGAGATAAATCAGGTAACAAACGGTTTTATGAGGCATTGATAAAAGTGGCTGACACGCAGCTGGC
GCACCACCTTGCAGACCTGGAGAGTGAATATGAAAACCTTAACTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11076.87 Da        Isoelectric Point: 7.0166

>AT81470 WP_061276561.1 NZ_CP023525:1559789-1560085 [Cedecea neteri]
MKTLTEVIAGFSPEDQAEIRKMTEVLILETGLQLVREEQGLSQKQVAQKMGISQPAIAAIEQRGNDLKVLTLKRYVEALG
GKLSLHLEFPERDRRFQI

Download         Length: 297 bp

>AT81470 NZ_CP023525:1559789-1560085 [Cedecea neteri]
ATGAAAACCTTAACTGAAGTGATTGCCGGGTTCTCGCCCGAAGACCAGGCAGAGATCCGAAAAATGACCGAAGTCTTAAT
TCTGGAAACTGGCCTGCAGCTGGTGCGTGAAGAACAGGGACTATCTCAAAAGCAAGTGGCACAAAAAATGGGTATTTCGC
AGCCGGCGATAGCCGCCATCGAACAGCGCGGTAACGATCTTAAGGTCCTTACTCTCAAGCGCTACGTTGAGGCCCTGGGC
GGCAAACTTTCGCTGCATCTGGAATTTCCGGAAAGGGACAGGCGTTTTCAGATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291DVU3

Antitoxin

Source ID Structure
AlphaFold DB A0A291DWC2

References