Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 2018194..2018849 Replicon chromosome
Accession NZ_CP023522
Organism Burkholderia gladioli pv. gladioli strain FDAARGOS_389

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CO712_RS09330 Protein ID WP_096750654.1
Coordinates 2018194..2018538 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CO712_RS09335 Protein ID WP_096749585.1
Coordinates 2018535..2018849 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO712_RS09310 2013837..2015123 + 1287 WP_096749581.1 glutamate-1-semialdehyde 2,1-aminomutase -
CO712_RS09315 2015145..2016263 + 1119 WP_096749582.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
CO712_RS09320 2016286..2016906 + 621 WP_096749583.1 riboflavin synthase -
CO712_RS36530 2017081..2017677 - 597 WP_124076068.1 hypothetical protein -
CO712_RS09330 2018194..2018538 + 345 WP_096750654.1 toxin Toxin
CO712_RS09335 2018535..2018849 + 315 WP_096749585.1 transcriptional regulator Antitoxin
CO712_RS09340 2018967..2019686 - 720 WP_036052482.1 DUF1223 domain-containing protein -
CO712_RS09345 2019882..2020319 + 438 WP_096749586.1 hypothetical protein -
CO712_RS09350 2020401..2021156 - 756 WP_036034318.1 molybdopterin-dependent oxidoreductase -
CO712_RS09355 2021156..2021782 - 627 WP_013696902.1 cytochrome b/b6 domain-containing protein -
CO712_RS09360 2021844..2022527 - 684 WP_013696901.1 hypothetical protein -
CO712_RS37355 2022665..2022973 + 309 WP_175427756.1 hypothetical protein -
CO712_RS09370 2023080..2023793 - 714 WP_096749588.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(45-90)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13284.15 Da        Isoelectric Point: 9.5443

>T81455 WP_096750654.1 NZ_CP023522:2018194-2018538 [Burkholderia gladioli pv. gladioli]
VQATFIELPPFSRERENYLADDEYAVLQKALLANPEAGDLIKGAGGLRKLRFADKGRQKGKRGGLRVIYYYWVSVYPFWL
FTLYDKDEMTDLSSDERKAFAKRLEREVTIRSQQ

Download         Length: 345 bp

>T81455 NZ_CP023522:2018194-2018538 [Burkholderia gladioli pv. gladioli]
GTGCAAGCGACCTTCATTGAACTGCCACCGTTTTCTCGTGAACGCGAAAACTACCTGGCAGATGACGAGTACGCCGTCCT
GCAGAAAGCGCTGCTGGCTAATCCCGAGGCTGGTGACCTGATCAAGGGAGCCGGCGGTCTGCGGAAATTGAGGTTCGCCG
ACAAAGGCCGCCAGAAAGGCAAGCGCGGTGGCCTACGAGTGATCTATTACTACTGGGTCAGCGTTTATCCATTCTGGTTG
TTCACGCTGTACGACAAAGATGAAATGACAGACCTCTCCAGTGACGAGCGCAAAGCCTTCGCGAAGCGATTGGAAAGAGA
AGTCACGATACGGAGCCAGCAATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11426.27 Da        Isoelectric Point: 10.4005

>AT81455 WP_096749585.1 NZ_CP023522:2018535-2018849 [Burkholderia gladioli pv. gladioli]
MKKRNLFAELTEGLDALAAEHEGKITLRKITAAVPDALEISPAEIKAVREASHASQAVMARSLRINVRTYQNWEQGKAKP
NAQAATLIRLVAKHPETLQMLATL

Download         Length: 315 bp

>AT81455 NZ_CP023522:2018535-2018849 [Burkholderia gladioli pv. gladioli]
ATGAAGAAGCGAAATCTGTTTGCTGAATTGACCGAGGGCCTCGATGCCCTTGCCGCCGAGCACGAAGGGAAAATCACGCT
GCGCAAGATCACAGCCGCTGTGCCCGATGCGCTCGAAATCTCGCCGGCAGAAATCAAGGCCGTGCGCGAAGCTTCTCACG
CGTCGCAAGCCGTCATGGCTCGAAGCCTGCGCATCAACGTGCGCACGTATCAGAATTGGGAACAAGGCAAGGCCAAGCCC
AACGCACAGGCGGCTACACTGATCCGACTGGTCGCCAAGCACCCGGAAACACTTCAGATGCTGGCAACTCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References