Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3017429..3018044 Replicon chromosome
Accession NZ_CP023521
Organism Burkholderia cepacia strain FDAARGOS_388

Toxin (Protein)


Gene name higB Uniprot ID A0A806VP16
Locus tag CO711_RS38535 Protein ID WP_027789973.1
Coordinates 3017703..3018044 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A806UZQ0
Locus tag CO711_RS38530 Protein ID WP_027789974.1
Coordinates 3017429..3017716 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO711_RS38500 3012972..3013751 - 780 WP_027789979.1 5'/3'-nucleotidase SurE -
CO711_RS38505 3014070..3014378 - 309 WP_027789978.1 AzlD family protein -
CO711_RS38510 3014371..3015105 - 735 WP_027789977.1 AzlC family ABC transporter permease -
CO711_RS38515 3015232..3015690 + 459 WP_006749370.1 Lrp/AsnC family transcriptional regulator -
CO711_RS38520 3015911..3016480 + 570 WP_027789976.1 hypothetical protein -
CO711_RS38525 3016660..3017349 + 690 WP_027789975.1 YebB family permuted papain-like enzyme -
CO711_RS38530 3017429..3017716 - 288 WP_027789974.1 helix-turn-helix transcriptional regulator Antitoxin
CO711_RS38535 3017703..3018044 - 342 WP_027789973.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CO711_RS38540 3018260..3018892 - 633 WP_027789972.1 LysE family translocator -
CO711_RS38545 3019322..3020959 + 1638 WP_027789971.1 ShlB/FhaC/HecB family hemolysin secretion/activation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(21-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-90)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13112.25 Da        Isoelectric Point: 9.5171

>T81454 WP_027789973.1 NZ_CP023521:c3018044-3017703 [Burkholderia cepacia]
MRTVADEIHFFSEQVEAGVFALPKTLIARFFALADRMEQYGPNPGEPHTRPMGDGLYEMRLKGLEDIARVFYCAVVNRRI
VMLHCYVKKTQKTPQKDLETARRRLKEIRDGNL

Download         Length: 342 bp

>T81454 NZ_CP023521:c3018044-3017703 [Burkholderia cepacia]
ATGCGAACCGTCGCGGATGAAATCCATTTCTTCAGCGAGCAAGTCGAGGCTGGCGTATTTGCGTTGCCGAAAACGCTGAT
CGCCAGATTCTTCGCACTCGCTGACCGCATGGAGCAGTACGGCCCGAATCCGGGCGAACCTCACACCAGGCCGATGGGCG
ACGGGTTGTACGAAATGCGGTTGAAGGGCCTGGAAGATATCGCACGTGTGTTTTACTGCGCGGTCGTCAACCGGCGGATC
GTCATGCTTCACTGCTACGTGAAGAAGACGCAGAAAACGCCGCAGAAGGACCTGGAAACCGCGCGCCGCCGATTGAAGGA
GATTCGAGATGGCAACCTATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10296.90 Da        Isoelectric Point: 9.6540

>AT81454 WP_027789974.1 NZ_CP023521:c3017716-3017429 [Burkholderia cepacia]
MATYKALRERALADPTVCAEYDRLNREEFALLDAMLAARRAAGLSQADVAERMGTKAPAVTRLERALATGQHSPSIDTLR
KYAAACGKKLVISFA

Download         Length: 288 bp

>AT81454 NZ_CP023521:c3017716-3017429 [Burkholderia cepacia]
ATGGCAACCTATAAGGCACTGCGCGAGCGCGCGTTGGCCGATCCGACGGTATGCGCCGAGTACGACCGGCTGAACCGCGA
GGAATTCGCGCTGCTCGACGCAATGCTGGCCGCCCGGCGAGCCGCCGGTCTTTCGCAAGCCGATGTGGCAGAGCGCATGG
GCACGAAGGCGCCTGCCGTCACGCGGCTCGAACGTGCGCTCGCGACAGGCCAGCACTCGCCGTCGATTGATACGCTGCGC
AAGTATGCGGCCGCATGCGGCAAGAAACTCGTGATCTCTTTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806VP16

Antitoxin

Source ID Structure
AlphaFold DB A0A806UZQ0

References