Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2978970..2979627 Replicon chromosome
Accession NZ_CP023521
Organism Burkholderia cepacia strain FDAARGOS_388

Toxin (Protein)


Gene name higB Uniprot ID A0A806V1Y2
Locus tag CO711_RS38345 Protein ID WP_027790007.1
Coordinates 2978970..2979302 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4S5CU29
Locus tag CO711_RS38350 Protein ID WP_027790006.1
Coordinates 2979295..2979627 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO711_RS38330 2974883..2976025 + 1143 WP_027790010.1 branched-chain amino acid ABC transporter substrate-binding protein -
CO711_RS38335 2976106..2976975 - 870 WP_027790009.1 mechanosensitive ion channel family protein -
CO711_RS38340 2977316..2978680 + 1365 WP_027790008.1 M23 family metallopeptidase -
CO711_RS38345 2978970..2979302 + 333 WP_027790007.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CO711_RS38350 2979295..2979627 + 333 WP_027790006.1 helix-turn-helix domain-containing protein Antitoxin
CO711_RS38355 2979814..2980659 - 846 WP_027790005.1 AraC family transcriptional regulator -
CO711_RS38360 2980813..2981634 - 822 WP_027790004.1 fucose-binding lectin II -
CO711_RS38365 2981759..2982148 - 390 WP_027790003.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2966796..2979627 12831


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(52-105)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12948.12 Da        Isoelectric Point: 10.0669

>T81453 WP_027790007.1 NZ_CP023521:2978970-2979302 [Burkholderia cepacia]
MKKWTILYYDERVKRDVFALPKGILAGYLRLIEAMEEHGADLRMPYSRAMGEGLFELRPRGREGIGRVFYCIRVGYELVV
LHSFVKKTQETPNDELQIARRRMKEVRNNG

Download         Length: 333 bp

>T81453 NZ_CP023521:2978970-2979302 [Burkholderia cepacia]
ATGAAGAAGTGGACGATCCTGTACTACGACGAACGGGTAAAGCGTGATGTGTTCGCTTTGCCCAAGGGCATTCTGGCTGG
CTACCTCCGACTGATCGAGGCGATGGAAGAACACGGTGCGGATCTGCGGATGCCGTATTCGCGCGCGATGGGGGAAGGAT
TGTTTGAATTGCGCCCGCGAGGCCGTGAAGGCATCGGGCGTGTGTTCTATTGCATCCGGGTGGGATATGAACTCGTCGTC
CTGCATTCCTTCGTCAAGAAGACGCAGGAAACACCCAACGACGAGTTGCAAATCGCCCGCAGGCGAATGAAGGAGGTACG
TAACAATGGCTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 11971.52 Da        Isoelectric Point: 8.0521

>AT81453 WP_027790006.1 NZ_CP023521:2979295-2979627 [Burkholderia cepacia]
MAKARPAHTSEERYAPVRHTAEDTARLLTDPAIKAEYDALEEEFTALRALLDARKDAGLTQAQVAERMGTTTSAVSRLEA
SFSSEKHSPSFATLRKYAAACGKKLVISFA

Download         Length: 333 bp

>AT81453 NZ_CP023521:2979295-2979627 [Burkholderia cepacia]
ATGGCTAAGGCTCGCCCCGCACATACAAGCGAGGAGCGGTATGCACCGGTCCGACACACTGCCGAAGACACCGCACGTCT
GCTCACCGATCCGGCCATCAAGGCGGAATACGATGCACTGGAAGAGGAGTTCACCGCGCTTCGTGCGTTGCTCGACGCGC
GCAAGGATGCGGGCCTGACTCAGGCTCAGGTCGCCGAACGAATGGGCACCACGACGTCGGCCGTATCGAGGCTCGAAGCT
TCGTTTTCGAGCGAGAAGCACTCGCCGTCGTTTGCGACGCTGCGCAAGTACGCCGCAGCGTGCGGCAAGAAGCTCGTCAT
TTCGTTCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806V1Y2

Antitoxin

Source ID Structure
AlphaFold DB A0A4S5CU29

References