Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 845973..846673 Replicon chromosome
Accession NZ_CP023521
Organism Burkholderia cepacia strain FDAARGOS_388

Toxin (Protein)


Gene name mqsR Uniprot ID A0A806V3J0
Locus tag CO711_RS28625 Protein ID WP_027791640.1
Coordinates 846377..846673 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A806V1K0
Locus tag CO711_RS28620 Protein ID WP_027791641.1
Coordinates 845973..846374 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO711_RS28600 841612..842964 - 1353 WP_027791645.1 LLM class flavin-dependent oxidoreductase -
CO711_RS28605 842972..844021 - 1050 WP_027791644.1 LLM class flavin-dependent oxidoreductase -
CO711_RS28610 844085..845038 - 954 WP_027791643.1 ABC transporter substrate-binding protein -
CO711_RS28615 845095..845655 - 561 WP_027791642.1 GNAT family N-acetyltransferase -
CO711_RS28620 845973..846374 - 402 WP_027791641.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
CO711_RS28625 846377..846673 - 297 WP_027791640.1 type II toxin-antitoxin system MqsR family toxin Toxin
CO711_RS28630 846777..847817 - 1041 WP_027791639.1 succinylglutamate desuccinylase/aspartoacylase family protein -
CO711_RS28635 848072..848347 - 276 WP_027791638.1 hypothetical protein -
CO711_RS28640 848591..850141 - 1551 WP_027791637.1 sensor domain-containing diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(74-127)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11203.05 Da        Isoelectric Point: 8.0535

>T81449 WP_027791640.1 NZ_CP023521:c846673-846377 [Burkholderia cepacia]
MEKRRPHCKLPLVKALVESGQVRLTASAVLGARQLGFTEREALDVVMSLTDLDFHKSMTTYADHTIWQDVYRPLTVRGDV
YLKLTVIDDVLIVSFKER

Download         Length: 297 bp

>T81449 NZ_CP023521:c846673-846377 [Burkholderia cepacia]
ATGGAAAAGAGAAGGCCTCATTGCAAGCTGCCCCTCGTCAAGGCGCTGGTCGAATCCGGCCAGGTCCGGTTGACCGCGAG
CGCGGTACTCGGCGCGCGGCAGCTGGGTTTCACGGAACGGGAGGCGCTCGATGTCGTGATGTCGCTGACCGACCTCGACT
TCCACAAGAGCATGACGACGTACGCCGACCACACGATCTGGCAGGACGTCTACCGGCCGTTGACGGTGCGTGGCGACGTG
TACCTGAAACTGACGGTGATCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14549.82 Da        Isoelectric Point: 8.8305

>AT81449 WP_027791641.1 NZ_CP023521:c846374-845973 [Burkholderia cepacia]
MKCPACGAAKLVRDTRDIPYTYKGRSTVVRAVTGEFCPACGESVLDLDEATRLGEAISEFNKQVNATIVDPNYIAKVRKK
LKLDQREAAELFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLAEVRAA

Download         Length: 402 bp

>AT81449 NZ_CP023521:c846374-845973 [Burkholderia cepacia]
ATGAAGTGTCCTGCATGCGGTGCTGCGAAGCTCGTCCGCGACACGCGCGACATCCCTTATACCTACAAGGGCCGGTCGAC
TGTCGTCCGCGCTGTCACCGGCGAGTTCTGCCCGGCCTGCGGGGAATCGGTGCTGGATCTCGACGAAGCGACCCGTCTCG
GCGAAGCGATCAGCGAGTTCAACAAGCAGGTGAACGCCACCATCGTCGACCCGAATTACATCGCGAAGGTGCGCAAGAAG
CTGAAGCTCGACCAGCGCGAGGCGGCCGAGCTTTTCGGCGGCGGCGTCAACGCGTTCTCCCGTTACGAAACAGGCAAGAC
GAATCCGCCGCTTGCCCTCGTGAAACTGCTGAAGATCCTCGATCGTCATCCCGATCTGCTCGCCGAAGTCCGGGCCGCAT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806V3J0

Antitoxin

Source ID Structure
AlphaFold DB A0A806V1K0

References