Detailed information of TA system TA081438

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1466333..1466845
• Replicon: chromosome
• Accession: NZ_CP023507
• Organism: Streptococcus oralis strain FDAARGOS_367

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: CO686_RS07240
• Protein ID: WP_096753672.1
• Coordinates: 1466333..1466587 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: CO686_RS07245
• Protein ID: WP_172844178.1
• Coordinates: 1466591..1466845 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CO686_RS07225	1461832..1462659	+	828	WP_000539525.1	DUF4839 domain-containing protein	-
CO686_RS07230	1462727..1464340	-	1614	WP_096753670.1	ribonuclease Y	-
CO686_RS07235	1464467..1466131	-	1665	WP_096753671.1	NTPase	-
CO686_RS07240	1466333..1466587	-	255	WP_096753672.1	Txe/YoeB family addiction module toxin	Toxin
CO686_RS07245	1466591..1466845	-	255	WP_172844178.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CO686_RS07250	1466978..1468075	-	1098	WP_065371603.1	nucleotidyltransferase	-
CO686_RS07255	1468085..1468825	-	741	WP_162279113.1	class I SAM-dependent methyltransferase	-
CO686_RS07265	1469146..1469499	-	354	WP_070800091.1	ribosome silencing factor	-
CO686_RS07270	1469500..1470093	-	594	WP_096753673.1	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK	-
CO686_RS07275	1470093..1470722	-	630	WP_096753674.1	nicotinate-nucleotide adenylyltransferase	-
CO686_RS07280	1470774..1471085	-	312	WP_000060169.1	ribosome assembly RNA-binding protein YhbY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10153.66 Da
• Isoelectric Point: 7.9660

>T81438 WP_096753672.1 NZ_CP023507:c1466587-1466333 [Streptococcus oralis]
MLLKFTEDAWADYCYWQTQDKKTLKRINMLIKDIQRDPFSGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSIAFLSF
KYHY

Nucleotide

• Length: 255 bp

>T81438 NZ_CP023507:c1466587-1466333 [Streptococcus oralis]
ATGCTGCTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTATTGGCAAACTCAGGATAAGAAGACATTAAAAAGAAT
CAACATGCTAATCAAGGATATTCAACGCGATCCTTTTTCAGGAATTGGGAAACCAGAACCGCTCAAGTATGATTATCAAG
GAGCTTGGTCACGACGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCATCGCTTTCTTGTCCTTC
AAATATCACTACTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9717.99 Da
• Isoelectric Point: 4.8550

>AT81438 WP_172844178.1 NZ_CP023507:c1466845-1466591 [Streptococcus oralis]
MEAVLYSTFRNHLKDYMKKVNEEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGISQVRAGSTQVH
VIEE

Nucleotide

• Length: 255 bp

>AT81438 NZ_CP023507:c1466845-1466591 [Streptococcus oralis]
ATGGAAGCAGTTCTTTATTCAACATTCCGAAATCATTTAAAAGACTACATGAAAAAGGTAAATGAAGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCTGATGAGGATATTGTTGTCCTTTCAAAGAGCGAGTGGGATAGTATTCAAGAAACCTTGA
GAATCGCTCAGAACAAGGAGCTTTCTGACAAGGTCTTGCGAGGAATTTCTCAAGTCCGAGCTGGAAGTACTCAGGTCCAT
GTTATTGAGGAGTGA