Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-couple_hipB
Location 1423909..1424557 Replicon chromosome
Accession NZ_CP023507
Organism Streptococcus oralis strain FDAARGOS_367

Toxin (Protein)


Gene name higB Uniprot ID A0A081R2L1
Locus tag CO686_RS07070 Protein ID WP_042902787.1
Coordinates 1424192..1424557 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G6C8B5
Locus tag CO686_RS07065 Protein ID WP_000797736.1
Coordinates 1423909..1424202 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO686_RS07055 1420345..1421211 - 867 WP_061421607.1 methylenetetrahydrofolate reductase [NAD(P)H] -
CO686_RS07060 1421306..1423555 - 2250 WP_096753654.1 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase -
CO686_RS07065 1423909..1424202 - 294 WP_000797736.1 helix-turn-helix transcriptional regulator Antitoxin
CO686_RS07070 1424192..1424557 - 366 WP_042902787.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CO686_RS07075 1424714..1425079 - 366 WP_049501081.1 TIGR02328 family protein -
CO686_RS07080 1425063..1425467 - 405 WP_096753655.1 YbgA family protein -
CO686_RS07085 1425598..1426683 - 1086 WP_096753656.1 HigA family addiction module antidote protein -
CO686_RS07090 1426676..1427014 - 339 WP_096753657.1 type II toxin-antitoxin system RelE/ParE family toxin -
CO686_RS07095 1427146..1428747 - 1602 WP_096753658.1 type I restriction-modification system subunit M -
CO686_RS07100 1428793..1429548 - 756 WP_096753659.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(36-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-88)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14549.72 Da        Isoelectric Point: 9.7755

>T81437 WP_042902787.1 NZ_CP023507:c1424557-1424192 [Streptococcus oralis]
VHTIYFYKDKNGNEPVLDYMRELARKKSKDSRIKLNKLNDYIELLSQHGTRTGEPYIKHLEDEIWELRPLKDRILFVAWV
DGSFVLLHHFVKKTQKTPRREIDKAKRELKDIKERGLSDEE

Download         Length: 366 bp

>T81437 NZ_CP023507:c1424557-1424192 [Streptococcus oralis]
GTGCATACAATTTACTTCTATAAGGACAAAAATGGAAATGAGCCAGTCTTAGATTATATGAGAGAATTGGCTAGAAAGAA
GAGTAAGGACAGTCGCATCAAACTCAATAAACTAAACGACTATATCGAGTTGCTTAGTCAGCATGGGACTAGAACTGGTG
AACCCTATATCAAACATTTGGAAGATGAGATTTGGGAACTACGACCTCTTAAGGATAGGATTTTATTTGTAGCATGGGTT
GATGGGAGTTTTGTTCTTTTACATCATTTTGTTAAAAAGACTCAGAAAACTCCTAGGAGAGAGATTGATAAAGCCAAGCG
TGAACTGAAAGACATAAAAGAAAGAGGGTTAAGTGATGAAGAATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10752.41 Da        Isoelectric Point: 5.1991

>AT81437 WP_000797736.1 NZ_CP023507:c1424202-1423909 [Streptococcus oralis]
MKNSAIGSNWKDIRSELFTKEEILESDMRVAIMSELIEARHEQGISQKKLEELSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEQEKS

Download         Length: 294 bp

>AT81437 NZ_CP023507:c1424202-1423909 [Streptococcus oralis]
ATGAAGAATAGTGCTATTGGAAGTAATTGGAAAGATATCCGATCTGAACTCTTTACCAAGGAGGAAATCCTTGAAAGTGA
TATGCGAGTGGCTATCATGAGTGAGTTGATAGAAGCTAGACATGAGCAAGGTATTAGTCAGAAAAAGCTAGAAGAACTCA
GTGGAGTAAGCCAGCCTGTCATAGCTAGAATGGAAACAGGAAAGACCAGTCCTCAGTTGGATACAGTCTTGAAAGTCTTA
GCCAGTTTAGGAAAGACACTAGCAGTCGTCCCACTTGAACAGGAAAAAAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A081R2L1

Antitoxin

Source ID Structure
AlphaFold DB A0A081R2L0

References