Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2075994..2076556 Replicon chromosome
Accession NZ_CP023504
Organism Citrobacter werkmanii strain FDAARGOS_364

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CO701_RS10325 Protein ID WP_096757033.1
Coordinates 2076278..2076556 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CO701_RS10320 Protein ID WP_096757032.1
Coordinates 2075994..2076278 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO701_RS10305 2071295..2074342 + 3048 WP_137398860.1 formate dehydrogenase-N subunit alpha -
CO701_RS10310 2074356..2075240 + 885 WP_096757030.1 formate dehydrogenase N subunit beta -
CO701_RS10315 2075233..2075889 + 657 WP_096757031.1 formate dehydrogenase-N subunit gamma -
CO701_RS10320 2075994..2076278 - 285 WP_096757032.1 HigA family addiction module antidote protein Antitoxin
CO701_RS10325 2076278..2076556 - 279 WP_096757033.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CO701_RS10330 2076744..2078459 - 1716 WP_096757034.1 ATP-binding cassette domain-containing protein -
CO701_RS10335 2078770..2080467 - 1698 WP_096757035.1 malate dehydrogenase -
CO701_RS10340 2080647..2080787 - 141 WP_096757036.1 stationary-phase-induced ribosome-associated protein -
CO701_RS10345 2081016..2081447 + 432 WP_096757037.1 OsmC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10601.05 Da        Isoelectric Point: 9.5320

>T81423 WP_096757033.1 NZ_CP023504:c2076556-2076278 [Citrobacter werkmanii]
MIMNFRHKGLRDLFLQGRTSGVTAKHVRRLRHRLAVIDAASHVTDINMPGYKLHALTGDRDGVWSISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T81423 NZ_CP023504:c2076556-2076278 [Citrobacter werkmanii]
ATGATCATGAACTTCAGACACAAAGGATTGCGCGACTTGTTTCTTCAGGGGCGAACATCAGGCGTGACGGCGAAGCATGT
CCGGCGATTGCGGCACCGACTTGCCGTTATTGATGCAGCGAGCCATGTAACAGATATCAATATGCCTGGTTATAAACTGC
ATGCGTTAACTGGCGATCGCGACGGCGTTTGGTCGATTTCTGTTTCAGGCAACTGGCGTATTACGTTTGAATTCGTCAAT
GGCGATGCATATATACTGGATTACGAGGACTATCATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10327.05 Da        Isoelectric Point: 8.8094

>AT81423 WP_096757032.1 NZ_CP023504:c2076278-2075994 [Citrobacter werkmanii]
MKMANHPRPGDIIQEALDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPEMWLNLQNAWSLAEAQ
KSVDISRLRKLVAQ

Download         Length: 285 bp

>AT81423 NZ_CP023504:c2076278-2075994 [Citrobacter werkmanii]
ATGAAAATGGCTAATCATCCCCGTCCGGGGGATATTATTCAGGAAGCGCTGGATGAGTTAAACGTCAGCCTGCGCGAATT
TGCCAGAGCAATGGAGATTGCCCCCTCAACCGCGAGCCGACTGTTAACGGGCAAGGCAGCATTAACCCCGGAAATGGCGA
TCAAACTTTCAGTGGTGATCGGCAGTTCGCCCGAAATGTGGTTGAATCTGCAGAATGCCTGGAGTCTGGCTGAAGCGCAA
AAAAGCGTGGATATCTCACGTCTGCGCAAACTGGTAGCACAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References