Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2197390..2197574 Replicon chromosome
Accession NZ_CP023500
Organism Staphylococcus aureus strain FDAARGOS_412

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag CO684_RS11660 Protein ID WP_000482650.1
Coordinates 2197467..2197574 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2197390..2197450 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO684_RS11635 2192920..2193087 - 168 WP_001790576.1 hypothetical protein -
CO684_RS11645 2193318..2195051 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
CO684_RS11650 2195076..2196839 - 1764 WP_058330317.1 ABC transporter ATP-binding protein/permease -
- 2197390..2197450 + 61 - - Antitoxin
CO684_RS11660 2197467..2197574 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
CO684_RS11665 2197708..2198094 - 387 WP_000779358.1 flippase GtxA -
CO684_RS11670 2198362..2199504 + 1143 WP_001176863.1 glycerate kinase -
CO684_RS11675 2199564..2200223 + 660 WP_000831298.1 membrane protein -
CO684_RS11680 2200405..2201616 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
CO684_RS11685 2201739..2202212 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T81409 WP_000482650.1 NZ_CP023500:c2197574-2197467 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T81409 NZ_CP023500:c2197574-2197467 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT81409 NZ_CP023500:2197390-2197450 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References