Detailed information of TA system TA081403

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 1754253..1754676
• Replicon: chromosome
• Accession: NZ_CP023500
• Organism: Staphylococcus aureus strain FDAARGOS_412

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A5S9I4Y6
• Locus tag: CO684_RS09200
• Protein ID: WP_001065091.1
• Coordinates: 1754425..1754676 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A0E0VQM8
• Locus tag: CO684_RS09195
• Protein ID: WP_000028422.1
• Coordinates: 1754253..1754435 (-)
• Length: 61 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CO684_RS09150	1749639..1751300	-	1662	WP_000625088.1	terminase large subunit	-
CO684_RS09155	1751297..1751641	-	345	WP_000402904.1	hypothetical protein	-
CO684_RS09160	1751771..1752070	-	300	WP_000988336.1	HNH endonuclease	-
CO684_RS09165	1752302..1752718	-	417	WP_000590122.1	hypothetical protein	-
CO684_RS09170	1752746..1752946	-	201	WP_000265043.1	DUF1514 family protein	-
CO684_RS09175	1752946..1753095	-	150	WP_000595265.1	transcriptional activator RinB	-
CO684_RS09180	1753092..1753478	-	387	WP_000592210.1	hypothetical protein	-
CO684_RS09185	1753475..1753681	-	207	WP_000195803.1	DUF1381 domain-containing protein	-
CO684_RS09190	1753718..1754260	-	543	WP_000185659.1	dUTP pyrophosphatase	-
CO684_RS09195	1754253..1754435	-	183	WP_000028422.1	hypothetical protein	Antitoxin
CO684_RS09200	1754425..1754676	-	252	WP_001065091.1	DUF1024 family protein	Toxin
CO684_RS14490	1754669..1754836	-	168	WP_001624242.1	hypothetical protein	-
CO684_RS09205	1754848..1755090	-	243	WP_000131366.1	hypothetical protein	-
CO684_RS09210	1755094..1755462	-	369	WP_000101274.1	hypothetical protein	-
CO684_RS09215	1755475..1755879	-	405	WP_000401960.1	RusA family crossover junction endodeoxyribonuclease	-
CO684_RS09220	1755888..1756106	-	219	WP_000338530.1	hypothetical protein	-
CO684_RS09225	1756113..1756997	-	885	WP_000148316.1	DnaD domain protein	-
CO684_RS09230	1757027..1757497	-	471	WP_000934764.1	single-stranded DNA-binding protein	-
CO684_RS09235	1757498..1758115	-	618	WP_071621397.1	MBL fold metallo-hydrolase	-
CO684_RS09240	1758196..1759116	-	921	WP_000138472.1	recombinase RecT	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / chp / sak / sea / hlb / groEL / hld	1675965..1801462	125497

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9349.22 Da
• Isoelectric Point: 3.9473

>T81403 WP_001065091.1 NZ_CP023500:c1754676-1754425 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Nucleotide

• Length: 252 bp

>T81403 NZ_CP023500:c1754676-1754425 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCAGTTATAAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTTTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin

Protein

• Length: 61 a.a.
• Molecular weight: 6741.63 Da
• Isoelectric Point: 4.2658

>AT81403 WP_000028422.1 NZ_CP023500:c1754435-1754253 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Nucleotide

• Length: 183 bp

>AT81403 NZ_CP023500:c1754435-1754253 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGAGCAGGAAAATGACTAA

Structures

Toxin

• AlphaFold DB: A0A5S9I4Y6

Antitoxin

• AlphaFold DB: A0A0E0VQM8