Detailed information of TA system TA081399

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 1730942..1731241
• Replicon: chromosome
• Accession: NZ_CP023500
• Organism: Staphylococcus aureus strain FDAARGOS_412

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CO684_RS09050
• Protein ID: WP_011447039.1
• Coordinates: 1731065..1731241 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1730942..1730997 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CO684_RS09000	1726273..1726533	+	261	WP_001791826.1	hypothetical protein	-
CO684_RS09005	1726586..1726936	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
CO684_RS09010	1727621..1728070	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
CO684_RS09015	1728165..1728500	-	336	Protein_1665	SH3 domain-containing protein	-
CO684_RS09030	1729150..1729641	-	492	WP_000919350.1	staphylokinase	-
CO684_RS09035	1729832..1730587	-	756	WP_000861038.1	CHAP domain-containing protein	-
CO684_RS09040	1730599..1730853	-	255	WP_000611512.1	phage holin	-
CO684_RS09045	1730905..1731012	+	108	WP_001791821.1	hypothetical protein	-
-	1730934..1731073	+	140	NuclAT_0	-	-
-	1730934..1731073	+	140	NuclAT_0	-	-
-	1730934..1731073	+	140	NuclAT_0	-	-
-	1730934..1731073	+	140	NuclAT_0	-	-
-	1730942..1730997	+	56	-	-	Antitoxin
CO684_RS09050	1731065..1731241	-	177	WP_011447039.1	putative holin-like toxin	Toxin
CO684_RS09055	1731350..1732123	-	774	WP_000750406.1	staphylococcal enterotoxin type A	-
CO684_RS09065	1732544..1732918	-	375	WP_000340977.1	hypothetical protein	-
CO684_RS09070	1732974..1733261	-	288	WP_001040259.1	hypothetical protein	-
CO684_RS09075	1733308..1733460	-	153	WP_001153681.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / chp / sak / sea / hlb / groEL / hld	1675965..1801462	125497

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T81399 WP_011447039.1 NZ_CP023500:c1731241-1731065 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T81399 NZ_CP023500:c1731241-1731065 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT81399 NZ_CP023500:1730942-1730997 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin