Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 1673095..1673756 | Replicon | chromosome |
| Accession | NZ_CP023482 | ||
| Organism | Dermabacter jinjuensis strain 32T | ||
Toxin (Protein)
| Gene name | HigB2 | Uniprot ID | S3XZV4 |
| Locus tag | COP05_RS07660 | Protein ID | WP_016664127.1 |
| Coordinates | 1673406..1673756 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | HigA2 | Uniprot ID | - |
| Locus tag | COP05_RS07655 | Protein ID | WP_016664128.1 |
| Coordinates | 1673095..1673400 (-) | Length | 102 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| COP05_RS07620 | 1668452..1668835 | + | 384 | WP_016664134.1 | MerR family transcriptional regulator | - |
| COP05_RS07625 | 1669078..1669530 | + | 453 | Protein_1470 | flavin-dependent oxidoreductase | - |
| COP05_RS07630 | 1669613..1669972 | + | 360 | WP_096883184.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| COP05_RS07635 | 1669969..1671861 | + | 1893 | WP_096883185.1 | cadmium-translocating P-type ATPase | - |
| COP05_RS07640 | 1672099..1672539 | - | 441 | WP_016664130.1 | HIT family protein | - |
| COP05_RS07645 | 1672536..1672859 | - | 324 | WP_016664129.1 | HigA family addiction module antidote protein | - |
| COP05_RS07650 | 1672834..1673085 | - | 252 | WP_081976445.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| COP05_RS07655 | 1673095..1673400 | - | 306 | WP_016664128.1 | helix-turn-helix domain-containing protein | Antitoxin |
| COP05_RS07660 | 1673406..1673756 | - | 351 | WP_016664127.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| COP05_RS07665 | 1673929..1674288 | - | 360 | WP_016664126.1 | hypothetical protein | - |
| COP05_RS07675 | 1674644..1675195 | - | 552 | WP_101687312.1 | hypothetical protein | - |
| COP05_RS07680 | 1675603..1675917 | + | 315 | WP_161493661.1 | helix-turn-helix domain-containing protein | - |
| COP05_RS07685 | 1675917..1676759 | + | 843 | WP_016664123.1 | IS3 family transposase | - |
| COP05_RS07690 | 1676829..1677566 | - | 738 | WP_161493662.1 | antirestriction protein ArdA | - |
| COP05_RS07695 | 1677731..1678555 | - | 825 | WP_016664121.1 | twin-arginine translocation signal domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | cmx | - | 1673095..1693246 | 20151 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13214.99 Da Isoelectric Point: 4.7657
>T81343 WP_016664127.1 NZ_CP023482:c1673756-1673406 [Dermabacter jinjuensis]
MWNVDIELIAEWLASLDDDSRVQVIAAIELLEERGPQLGRPIVDTVSSSQHRNMKELRPGSAGRSELRVLFAFDPERSAI
MLIAGDKAGNWTRWYKTNVPLADDIFDEHLRKLRGE
MWNVDIELIAEWLASLDDDSRVQVIAAIELLEERGPQLGRPIVDTVSSSQHRNMKELRPGSAGRSELRVLFAFDPERSAI
MLIAGDKAGNWTRWYKTNVPLADDIFDEHLRKLRGE
Download Length: 351 bp
>T81343 NZ_CP023482:c1673756-1673406 [Dermabacter jinjuensis]
ATGTGGAACGTGGACATCGAGCTGATCGCCGAATGGCTCGCTTCGCTGGACGATGATTCGCGGGTGCAGGTGATAGCTGC
GATCGAGCTACTCGAAGAACGTGGCCCACAGCTCGGGCGGCCAATCGTTGACACTGTGTCGTCGTCACAACATCGCAACA
TGAAGGAGCTGCGGCCGGGTTCGGCTGGACGATCTGAGCTGCGCGTCTTGTTCGCATTCGATCCGGAGCGCTCAGCGATC
ATGTTGATCGCTGGCGACAAGGCTGGCAACTGGACGCGCTGGTACAAGACGAACGTTCCACTGGCCGACGACATTTTCGA
TGAACACCTGCGCAAATTGAGAGGAGAGTGA
ATGTGGAACGTGGACATCGAGCTGATCGCCGAATGGCTCGCTTCGCTGGACGATGATTCGCGGGTGCAGGTGATAGCTGC
GATCGAGCTACTCGAAGAACGTGGCCCACAGCTCGGGCGGCCAATCGTTGACACTGTGTCGTCGTCACAACATCGCAACA
TGAAGGAGCTGCGGCCGGGTTCGGCTGGACGATCTGAGCTGCGCGTCTTGTTCGCATTCGATCCGGAGCGCTCAGCGATC
ATGTTGATCGCTGGCGACAAGGCTGGCAACTGGACGCGCTGGTACAAGACGAACGTTCCACTGGCCGACGACATTTTCGA
TGAACACCTGCGCAAATTGAGAGGAGAGTGA
Antitoxin
Download Length: 102 a.a. Molecular weight: 11249.75 Da Isoelectric Point: 6.8816
>AT81343 WP_016664128.1 NZ_CP023482:c1673400-1673095 [Dermabacter jinjuensis]
MALSLKDFVAEHPVDRERVDAHKERMLAETRAYRLRELREDAGLTQAQLAARIGVGQRQVSKIEHGDLDNAKVGTIRNYL
EAVGGGLSIEYVLGDHRVQVA
MALSLKDFVAEHPVDRERVDAHKERMLAETRAYRLRELREDAGLTQAQLAARIGVGQRQVSKIEHGDLDNAKVGTIRNYL
EAVGGGLSIEYVLGDHRVQVA
Download Length: 306 bp
>AT81343 NZ_CP023482:c1673400-1673095 [Dermabacter jinjuensis]
ATGGCCCTGTCACTGAAGGACTTTGTCGCCGAGCATCCCGTGGACCGCGAGCGCGTCGACGCGCATAAGGAGAGGATGCT
CGCCGAGACGCGCGCATACCGACTCCGTGAGCTTCGTGAAGATGCTGGTCTAACGCAGGCGCAGCTCGCTGCACGCATCG
GCGTGGGTCAGCGTCAGGTCTCCAAGATCGAGCATGGCGACCTTGATAATGCGAAGGTCGGTACGATCCGCAATTACCTT
GAGGCGGTTGGCGGCGGTCTGTCGATCGAGTATGTTCTGGGCGATCATCGCGTCCAAGTGGCCTGA
ATGGCCCTGTCACTGAAGGACTTTGTCGCCGAGCATCCCGTGGACCGCGAGCGCGTCGACGCGCATAAGGAGAGGATGCT
CGCCGAGACGCGCGCATACCGACTCCGTGAGCTTCGTGAAGATGCTGGTCTAACGCAGGCGCAGCTCGCTGCACGCATCG
GCGTGGGTCAGCGTCAGGTCTCCAAGATCGAGCATGGCGACCTTGATAATGCGAAGGTCGGTACGATCCGCAATTACCTT
GAGGCGGTTGGCGGCGGTCTGTCGATCGAGTATGTTCTGGGCGATCATCGCGTCCAAGTGGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|