81342

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_37
Location 1672834..1673400 Replicon chromosome
Accession NZ_CP023482
Organism Dermabacter jinjuensis strain 32T

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag COP05_RS07650 Protein ID WP_081976445.1
Coordinates 1672834..1673085 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag COP05_RS07655 Protein ID WP_016664128.1
Coordinates 1673095..1673400 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
COP05_RS07620 1668452..1668835 + 384 WP_016664134.1 MerR family transcriptional regulator -
COP05_RS07625 1669078..1669530 + 453 Protein_1470 flavin-dependent oxidoreductase -
COP05_RS07630 1669613..1669972 + 360 WP_096883184.1 metalloregulator ArsR/SmtB family transcription factor -
COP05_RS07635 1669969..1671861 + 1893 WP_096883185.1 cadmium-translocating P-type ATPase -
COP05_RS07640 1672099..1672539 - 441 WP_016664130.1 HIT family protein -
COP05_RS07645 1672536..1672859 - 324 WP_016664129.1 HigA family addiction module antidote protein -
COP05_RS07650 1672834..1673085 - 252 WP_081976445.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
COP05_RS07655 1673095..1673400 - 306 WP_016664128.1 helix-turn-helix domain-containing protein Antitoxin
COP05_RS07660 1673406..1673756 - 351 WP_016664127.1 type II toxin-antitoxin system RelE/ParE family toxin -
COP05_RS07665 1673929..1674288 - 360 WP_016664126.1 hypothetical protein -
COP05_RS07675 1674644..1675195 - 552 WP_101687312.1 hypothetical protein -
COP05_RS07680 1675603..1675917 + 315 WP_161493661.1 helix-turn-helix domain-containing protein -
COP05_RS07685 1675917..1676759 + 843 WP_016664123.1 IS3 family transposase -
COP05_RS07690 1676829..1677566 - 738 WP_161493662.1 antirestriction protein ArdA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-80)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-83)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9538.65 Da        Isoelectric Point: 8.8308

>T81342 WP_081976445.1 NZ_CP023482:c1673085-1672834 [Dermabacter jinjuensis]
VRRHGHACLNSVDSRVQNATTRKLTQTRTARFVDSRCIPPGNRLEPLNEDRVGQHSIRVNAQWRLCFVWRDGGADDVELV
DDR

Download         Length: 252 bp

>T81342 NZ_CP023482:c1673085-1672834 [Dermabacter jinjuensis]
GTGCGACGCCATGGCCATGCGTGCCTGAACTCGGTCGATTCCCGTGTCCAGAACGCAACCACACGAAAGCTGACGCAGAC
CCGCACTGCTCGATTCGTCGACTCGCGGTGCATACCGCCTGGCAACCGGTTAGAGCCACTAAACGAGGACCGCGTGGGAC
AGCACAGCATCCGCGTCAACGCACAATGGCGTCTCTGCTTCGTCTGGAGAGATGGAGGTGCAGACGATGTCGAACTCGTC
GACGACCGCTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11249.75 Da        Isoelectric Point: 6.8816

>AT81342 WP_016664128.1 NZ_CP023482:c1673400-1673095 [Dermabacter jinjuensis]
MALSLKDFVAEHPVDRERVDAHKERMLAETRAYRLRELREDAGLTQAQLAARIGVGQRQVSKIEHGDLDNAKVGTIRNYL
EAVGGGLSIEYVLGDHRVQVA

Download         Length: 306 bp

>AT81342 NZ_CP023482:c1673400-1673095 [Dermabacter jinjuensis]
ATGGCCCTGTCACTGAAGGACTTTGTCGCCGAGCATCCCGTGGACCGCGAGCGCGTCGACGCGCATAAGGAGAGGATGCT
CGCCGAGACGCGCGCATACCGACTCCGTGAGCTTCGTGAAGATGCTGGTCTAACGCAGGCGCAGCTCGCTGCACGCATCG
GCGTGGGTCAGCGTCAGGTCTCCAAGATCGAGCATGGCGACCTTGATAATGCGAAGGTCGGTACGATCCGCAATTACCTT
GAGGCGGTTGGCGGCGGTCTGTCGATCGAGTATGTTCTGGGCGATCATCGCGTCCAAGTGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References