81341

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1658918..1659488 Replicon chromosome
Accession NZ_CP023482
Organism Dermabacter jinjuensis strain 32T

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag COP05_RS07560 Protein ID WP_096883180.1
Coordinates 1658918..1659199 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag COP05_RS07565 Protein ID WP_096883181.1
Coordinates 1659186..1659488 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
COP05_RS07550 1657216..1658070 + 855 WP_065247467.1 23S ribosomal RNA methyltransferase Erm -
COP05_RS07560 1658918..1659199 + 282 WP_096883180.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
COP05_RS07565 1659186..1659488 + 303 WP_096883181.1 HigA family addiction module antidote protein Antitoxin
COP05_RS07570 1659796..1660191 + 396 WP_096883182.1 GNAT family N-acetyltransferase -
COP05_RS11245 1660293..1660775 - 483 WP_070460150.1 GNAT family N-acetyltransferase -
COP05_RS07575 1660761..1661267 - 507 Protein_1460 GNAT family N-acetyltransferase -
COP05_RS07580 1661530..1661925 + 396 WP_070459951.1 glyoxalase -
COP05_RS07585 1662231..1662584 - 354 WP_034372429.1 GNAT family N-acetyltransferase -
COP05_RS07590 1663083..1663625 + 543 WP_034372426.1 DUF488 domain-containing protein -
COP05_RS10970 1664076..1664129 + 54 WP_011113070.1 chloramphenicol resistance leader peptide -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn cmx - 1664151..1666315 2164


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10983.44 Da        Isoelectric Point: 10.0817

>T81341 WP_096883180.1 NZ_CP023482:1658918-1659199 [Dermabacter jinjuensis]
MIRSFGDKATERLWRRERVRSIDPRIHRVALRKLRQVGSAESLEDLRVPPGNRLEALKGDRAGQYSIRINDQWHIYFVWS
DAGPEEVQIVDYH

Download         Length: 282 bp

>T81341 NZ_CP023482:1658918-1659199 [Dermabacter jinjuensis]
ATGATCAGATCGTTCGGCGACAAGGCGACCGAACGGCTGTGGCGTCGTGAGCGCGTGCGGTCCATCGATCCGAGGATCCA
TCGCGTCGCACTGCGCAAGCTGCGTCAGGTGGGGTCCGCGGAGTCTCTCGAGGACCTCCGGGTCCCGCCCGGCAACCGGC
TCGAGGCCCTCAAGGGTGATAGGGCCGGGCAGTACAGCATCAGGATCAACGACCAGTGGCATATCTACTTCGTGTGGAGC
GACGCCGGACCGGAGGAGGTGCAGATCGTTGACTACCACTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11065.59 Da        Isoelectric Point: 4.8129

>AT81341 WP_096883181.1 NZ_CP023482:1659186-1659488 [Dermabacter jinjuensis]
MTTTDRIEPIHPGEVLMEDFIGGFGITQNKLAVSIGVPPRRINEIVHGKRGITADTALRLAKYFGTSAEFWMNLQSHYEL
DRAEDLAEEQIAAITPLQAA

Download         Length: 303 bp

>AT81341 NZ_CP023482:1659186-1659488 [Dermabacter jinjuensis]
TTGACTACCACTGACAGGATCGAGCCGATCCACCCGGGTGAGGTCCTCATGGAGGACTTCATCGGGGGCTTCGGCATCAC
GCAGAACAAGCTCGCCGTCTCGATCGGGGTTCCGCCGCGGCGGATCAATGAGATCGTGCACGGCAAGCGGGGCATCACTG
CCGACACCGCGCTGCGGCTCGCGAAGTACTTCGGCACGTCGGCGGAGTTCTGGATGAACCTGCAGAGCCACTACGAGTTG
GACCGTGCGGAGGACCTCGCGGAGGAGCAGATCGCGGCGATCACGCCCCTGCAGGCCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References