Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3721872..3722469 Replicon chromosome
Accession NZ_CP023478
Organism Klebsiella quasipneumoniae strain KPC142

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KPC142_RS18540 Protein ID WP_106939352.1
Coordinates 3722152..3722469 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KPC142_RS18535 Protein ID WP_106939351.1
Coordinates 3721872..3722159 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPC142_RS18505 3717959..3718207 + 249 WP_002893037.1 DUF1158 domain-containing protein -
KPC142_RS18510 3718225..3718566 - 342 WP_004202492.1 RamA family antibiotic efflux transcriptional regulator -
KPC142_RS18515 3718597..3719712 - 1116 WP_025999133.1 MBL fold metallo-hydrolase -
KPC142_RS18520 3719892..3720473 + 582 WP_017899014.1 TetR/AcrR family transcriptional regulator -
KPC142_RS18525 3720473..3720841 + 369 WP_004202487.1 MmcQ/YjbR family DNA-binding protein -
KPC142_RS18530 3720961..3721614 + 654 WP_004202485.1 oxygen-insensitive NAD(P)H nitroreductase -
KPC142_RS18535 3721872..3722159 - 288 WP_106939351.1 helix-turn-helix transcriptional regulator Antitoxin
KPC142_RS18540 3722152..3722469 - 318 WP_106939352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KPC142_RS18545 3722653..3723696 - 1044 WP_060656299.1 hypothetical protein -
KPC142_RS18555 3724234..3725100 - 867 WP_053810680.1 helix-turn-helix transcriptional regulator -
KPC142_RS18560 3725209..3726636 + 1428 WP_087832539.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12159.50 Da        Isoelectric Point: 11.6063

>T81334 WP_106939352.1 NZ_CP023478:c3722469-3722152 [Klebsiella quasipneumoniae]
MFRMVVHVDVKKELQALPAMVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQNKTLFLLRVF
VKKTQRTPLSGIRLALKRLEEMRNE

Download         Length: 318 bp

>T81334 NZ_CP023478:c3722469-3722152 [Klebsiella quasipneumoniae]
ATGTTCAGAATGGTTGTGCATGTGGACGTTAAAAAGGAGTTGCAGGCGCTTCCGGCTATGGTCCAGGCGAAGATGATCAG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGATAGTAAACCGCTTGGACAAGGGCTATTTGAAA
TTCGAGCGTTAGGTTCGGTACAGGGGCGGGGGATCTACGTTTTTCAGCAAAACAAAACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAGAACCCCGTTATCGGGAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10868.57 Da        Isoelectric Point: 10.2213

>AT81334 WP_106939351.1 NZ_CP023478:c3722159-3721872 [Klebsiella quasipneumoniae]
MSKKIIDWDTLKTELLSQPEVQVAFDAQERQHRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRTSLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT81334 NZ_CP023478:c3722159-3721872 [Klebsiella quasipneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTAGCCAGCCTGAGGTTCAGGTTGCGTTCGATGC
GCAAGAACGTCAGCACCGATTACGTACTATGCTGGCACAATGGCGCGAGCAGGCGGGGCTGACCCGAGCCCAGGTTGCGC
AGAGGATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCACCAGCCTGGATACCTTAACGCGA
TACGCGTTAGCGTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References