Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 175384..175897 Replicon chromosome
Accession NZ_CP023477
Organism Streptococcus mutans strain LAR01

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag CO204_RS00930 Protein ID WP_002270995.1
Coordinates 175384..175638 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag CO204_RS00935 Protein ID WP_002270994.1
Coordinates 175631..175897 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO204_RS00895 171260..171676 - 417 WP_002271002.1 conjugal transfer protein -
CO204_RS00900 171678..171905 - 228 WP_002271001.1 hypothetical protein -
CO204_RS00905 171922..172914 - 993 WP_002280082.1 conjugal transfer protein -
CO204_RS00910 172924..173478 - 555 WP_106006656.1 conjugal transfer protein -
CO204_RS00915 173475..173711 - 237 WP_002280080.1 hypothetical protein -
CO204_RS00920 173731..174117 - 387 WP_002280079.1 hypothetical protein -
CO204_RS00925 174095..175327 - 1233 WP_106006657.1 replication initiation factor domain-containing protein -
CO204_RS00930 175384..175638 - 255 WP_002270995.1 Txe/YoeB family addiction module toxin Toxin
CO204_RS00935 175631..175897 - 267 WP_002270994.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CO204_RS00940 176161..177819 - 1659 WP_106006658.1 cell division protein FtsK -
CO204_RS00945 177826..178236 - 411 WP_002280076.1 DUF961 family protein -
CO204_RS00950 178259..178573 - 315 WP_000406626.1 hypothetical protein -
CO204_RS00960 178912..179148 - 237 WP_002280074.1 hypothetical protein -
CO204_RS00965 179197..179475 - 279 WP_106006659.1 type II toxin-antitoxin system YafQ family toxin -
CO204_RS00970 179476..179748 - 273 WP_106006660.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
CO204_RS00975 179900..180613 + 714 WP_106006661.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10474.89 Da        Isoelectric Point: 8.3800

>T81319 WP_002270995.1 NZ_CP023477:c175638-175384 [Streptococcus mutans]
MFNFTEQAWKDYVSWQQEDKKILKRINRLIEDIKRNPFEGIGKPEPLKYRYSGAWSRRITDEHRLVYLVEEDEIYFLSFR
DHYK

Download         Length: 255 bp

>T81319 NZ_CP023477:c175638-175384 [Streptococcus mutans]
ATGTTTAACTTTACAGAACAAGCTTGGAAAGATTATGTTTCTTGGCAACAAGAAGATAAAAAGATACTCAAACGTATCAA
TCGTTTAATTGAGGATATCAAACGAAATCCTTTTGAAGGGATTGGAAAACCAGAGCCATTAAAATATCGTTATTCGGGTG
CTTGGTCTCGTAGAATTACAGATGAACACCGATTAGTCTATCTGGTTGAAGAAGATGAAATTTATTTCTTATCCTTTCGA
GACCATTATAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10422.91 Da        Isoelectric Point: 4.6437

>AT81319 WP_002270994.1 NZ_CP023477:c175897-175631 [Streptococcus mutans]
MEAVVYSNFRNNLKNYMKKVNDEYEPLMVVNKNPDENIVVLSKENWDSIQETIRLMNNDYLSDKVLSGMEQVKQKKVVQR
QLLEVEDV

Download         Length: 267 bp

>AT81319 NZ_CP023477:c175897-175631 [Streptococcus mutans]
ATGGAAGCTGTAGTCTATTCAAATTTCAGAAACAACTTAAAGAATTATATGAAAAAAGTCAATGATGAATATGAACCTCT
AATGGTTGTCAATAAAAACCCTGATGAAAATATTGTGGTCTTATCTAAGGAAAACTGGGATAGTATTCAAGAAACCATCC
GCCTAATGAATAACGATTATCTTTCAGACAAGGTTCTATCAGGGATGGAACAAGTTAAACAAAAGAAAGTCGTTCAACGC
CAATTATTAGAGGTGGAAGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References