Detailed information of TA system TA081279

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 113455..113975
• Replicon: chromosome
• Accession: NZ_CP023449
• Organism: Rhizorhabdus dicambivorans strain Ndbn-20

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A2A4FZR8
• Locus tag: CMV14_RS00530
• Protein ID: WP_066964600.1
• Coordinates: 113709..113975 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: CMV14_RS00525
• Protein ID: WP_066964603.1
• Coordinates: 113455..113712 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CMV14_RS00500	109677..110387	+	711	WP_066964614.1	uracil-DNA glycosylase	-
CMV14_RS00505	110452..110901	+	450	WP_066964612.1	pyridoxamine 5'-phosphate oxidase family protein	-
CMV14_RS00510	111017..111562	-	546	WP_066964799.1	permease	-
CMV14_RS00515	111700..112245	-	546	WP_066964609.1	2'-5' RNA ligase family protein	-
CMV14_RS00520	112344..112994	-	651	WP_066964606.1	glutathione S-transferase family protein	-
CMV14_RS00525	113455..113712	+	258	WP_066964603.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CMV14_RS00530	113709..113975	+	267	WP_066964600.1	Txe/YoeB family addiction module toxin	Toxin
CMV14_RS00535	113984..114310	-	327	WP_066964597.1	type II toxin-antitoxin system PemK/MazF family toxin	-
CMV14_RS00540	114307..114537	-	231	WP_066964594.1	DUF3018 family protein	-
CMV14_RS00545	114623..115288	-	666	WP_083215903.1	hypothetical protein	-
CMV14_RS00550	115662..117521	-	1860	WP_066964591.1	phosphomethylpyrimidine synthase ThiC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10335.77 Da
• Isoelectric Point: 9.5575

>T81279 WP_066964600.1 NZ_CP023449:113709-113975 [Rhizorhabdus dicambivorans]
VKLVFWPTAWEDYLHWQAEDPKLLARLNDLIKECRRNPFRGTGKPEPLGGNLSGWWSRRVNGEHRLVYRVSGKGEAQALE
IAQCRYHY

Nucleotide

• Length: 267 bp

>T81279 NZ_CP023449:113709-113975 [Rhizorhabdus dicambivorans]
GTGAAGCTGGTGTTCTGGCCGACGGCCTGGGAGGATTATCTCCACTGGCAGGCCGAGGACCCCAAGCTGCTCGCCCGTCT
CAACGACCTGATCAAGGAATGCCGCCGCAATCCCTTTCGCGGAACCGGCAAGCCCGAGCCGCTGGGCGGCAATCTGAGCG
GCTGGTGGTCCCGCCGGGTCAATGGCGAGCATCGGCTGGTCTATCGGGTCAGCGGCAAGGGCGAGGCGCAGGCGCTGGAG
ATCGCGCAGTGCCGGTATCATTATTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9371.54 Da
• Isoelectric Point: 4.2932

>AT81279 WP_066964603.1 NZ_CP023449:113455-113712 [Rhizorhabdus dicambivorans]
MDSISYSETRANLKAVMDKVVEDRAPVTITRARGQENVVMVSESEWASIEETLYLLRSPVNAARLLDAVRGLEAGGGEEH
ELIEP

Nucleotide

• Length: 258 bp

>AT81279 NZ_CP023449:113455-113712 [Rhizorhabdus dicambivorans]
ATGGACTCGATCAGCTATTCGGAAACCCGGGCCAATCTGAAGGCCGTCATGGACAAGGTGGTGGAAGACCGCGCCCCGGT
CACGATCACCCGCGCGCGCGGGCAGGAGAATGTGGTGATGGTTTCGGAAAGCGAATGGGCGTCGATCGAGGAGACGCTCT
ATCTGCTCCGCTCGCCCGTCAATGCCGCGCGCCTGCTGGACGCTGTCCGCGGGCTGGAGGCCGGCGGGGGCGAGGAGCAT
GAGCTGATCGAACCGTGA

Structures

Toxin

• AlphaFold DB: A0A2A4FZR8