Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4977765..4978272 Replicon chromosome
Accession NZ_CP023439
Organism Thauera sp. K11

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag CCZ27_RS21700 Protein ID WP_096451718.1
Coordinates 4977765..4978019 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag CCZ27_RS21705 Protein ID WP_096451720.1
Coordinates 4978000..4978272 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCZ27_RS21680 4973144..4973560 - 417 WP_096451710.1 transcriptional repressor -
CCZ27_RS21685 4973672..4974670 - 999 WP_198363220.1 cytochrome-c peroxidase -
CCZ27_RS21690 4974957..4975847 + 891 WP_096451714.1 LysR family transcriptional regulator -
CCZ27_RS21695 4975863..4977527 - 1665 WP_096451716.1 thiamine pyrophosphate-binding protein -
CCZ27_RS21700 4977765..4978019 - 255 WP_096451718.1 Txe/YoeB family addiction module toxin Toxin
CCZ27_RS21705 4978000..4978272 - 273 WP_096451720.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CCZ27_RS21710 4978312..4979735 + 1424 Protein_4338 integrase family protein -
CCZ27_RS21715 4979775..4980116 + 342 WP_096451722.1 type II toxin-antitoxin system RelE/ParE family toxin -
CCZ27_RS21720 4980113..4980400 + 288 WP_096451724.1 helix-turn-helix domain-containing protein -
CCZ27_RS21730 4981239..4981787 - 549 WP_096451726.1 crossover junction endodeoxyribonuclease RuvC -
CCZ27_RS21735 4981800..4982117 - 318 WP_096451728.1 heavy metal-binding domain-containing protein -
CCZ27_RS21740 4982200..4982925 - 726 WP_096451730.1 YebC/PmpR family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10184.52 Da        Isoelectric Point: 8.1110

>T81275 WP_096451718.1 NZ_CP023439:c4978019-4977765 [Thauera sp. K11]
MPLKFADHAWDDYVYWSQHDRKVLKRINQLIEDIRRHPFEGIGKPEPLKHQLSGFWSRRTDDRHRLVYAINGDDVLIAQC
RDHY

Download         Length: 255 bp

>T81275 NZ_CP023439:c4978019-4977765 [Thauera sp. K11]
ATGCCGCTGAAGTTCGCTGACCATGCGTGGGACGACTACGTCTATTGGAGCCAGCATGACCGCAAAGTCCTCAAGCGCAT
CAACCAACTGATCGAGGACATCCGGCGGCACCCCTTCGAGGGGATCGGCAAACCGGAACCCCTGAAGCATCAGCTCTCGG
GGTTCTGGTCCCGCCGGACCGATGATCGTCATCGACTCGTGTATGCGATCAATGGCGACGACGTCTTGATCGCGCAGTGC
CGGGACCACTATTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10027.30 Da        Isoelectric Point: 4.8182

>AT81275 WP_096451720.1 NZ_CP023439:c4978272-4978000 [Thauera sp. K11]
MDALTFSYTRAHLAEVMRTVNEDRAPVLVTTQRGKPVVIMSLDDYNALEETAYLLRNPKGARRLLDSVEQLRAGSGSVHE
PIDDDAAEVR

Download         Length: 273 bp

>AT81275 NZ_CP023439:c4978272-4978000 [Thauera sp. K11]
ATGGACGCCCTGACCTTCAGCTACACGCGAGCCCACCTCGCCGAGGTGATGCGCACCGTCAACGAGGACCGCGCGCCCGT
ACTCGTCACCACTCAACGCGGCAAGCCGGTGGTCATCATGTCGCTCGACGACTACAACGCCCTCGAAGAAACCGCATACC
TGCTGCGCAACCCCAAGGGCGCCCGCCGCTTGCTCGATTCGGTCGAACAGCTTCGTGCCGGCAGCGGCTCCGTGCATGAA
CCGATCGACGACGATGCCGCTGAAGTTCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References