Detailed information of TA system TA081219

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): bsrG-SR6/-
• Location: 2222925..2223214
• Replicon: chromosome
• Accession: NZ_CP023409
• Organism: Bacillus subtilis strain 7PJ-16

Toxin (Protein)

• Gene name: bsrG
• Uniprot ID: L8EAY0
• Locus tag: Bateq7PJ16_RS11910
• Protein ID: WP_009967548.1
• Coordinates: 2222925..2223041 (+)
• Length: 39 a.a.

Antitoxin (RNA)

Gene name	SR6
Locus tag	-
Coordinates	2223036..2223214 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Bateq7PJ16_RS11870	2218043..2218294	+	252	WP_159376903.1	phage holin	-
Bateq7PJ16_RS11875	2218449..2219564	+	1116	WP_159376904.1	response regulator aspartate phosphatase RapK	-
Bateq7PJ16_RS11880	2219561..2219683	+	123	WP_004399440.1	phosphatase RapK inhibitor PhrK	-
Bateq7PJ16_RS11885	2219738..2220988	-	1251	WP_159376905.1	UV damage repair protein UvrX	-
Bateq7PJ16_RS11890	2220981..2221313	-	333	WP_069322722.1	YolD-like family protein	-
Bateq7PJ16_RS11895	2221487..2221822	+	336	WP_159376906.1	hypothetical protein	-
Bateq7PJ16_RS11900	2221865..2222221	-	357	WP_019712874.1	hypothetical protein	-
Bateq7PJ16_RS11905	2222227..2222694	-	468	WP_159376907.1	YolA family protein	-
Bateq7PJ16_RS11910	2222925..2223041	+	117	WP_009967548.1	type I toxin-antitoxin system toxin BsrG	Toxin
-	2223036..2223214	-	179	NuclAT_1	-	Antitoxin
-	2223036..2223214	-	179	NuclAT_1	-	Antitoxin
-	2223036..2223214	-	179	NuclAT_1	-	Antitoxin
-	2223036..2223214	-	179	NuclAT_1	-	Antitoxin
Bateq7PJ16_RS11915	2223319..2223852	-	534	WP_004399156.1	GNAT family N-acetyltransferase	-
Bateq7PJ16_RS11920	2223888..2224466	-	579	WP_004399123.1	SMI1/KNR4 family protein	-
Bateq7PJ16_RS11925	2224530..2225027	-	498	WP_003246188.1	SMI1/KNR4 family protein	-
Bateq7PJ16_RS11930	2225036..2226751	-	1716	WP_004398855.1	ribonuclease YeeF family protein	-
Bateq7PJ16_RS11935	2226892..2227425	-	534	WP_159376908.1	SMI1/KNR4 family protein	-
Bateq7PJ16_RS11940	2227510..2227761	-	252	WP_159376909.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2102251..2231315	129064

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-38)

Sequences

Toxin

Protein

• Length: 39 a.a.
• Molecular weight: 4336.39 Da
• Isoelectric Point: 10.1022

>T81219 WP_009967548.1 NZ_CP023409:2222925-2223041 [Bacillus subtilis]
MTVYESLMIMINFGGLILNTVLLIFNIMMIVTSSQKKK

Nucleotide

• Length: 117 bp

>T81219 NZ_CP023409:2222925-2223041 [Bacillus subtilis]
ATGACTGTTTACGAATCATTAATGATAATGATCAATTTTGGCGGATTGATATTAAATACCGTCTTGTTGATCTTCAATAT
AATGATGATTGTAACGTCAAGCCAAAAGAAAAAATAG

Antitoxin

Nucleotide

• Length: 179 bp

>AT81219 NZ_CP023409:c2223214-2223036 [Bacillus subtilis]
AATGATACAAATAATTATTTTTTGCATTTTGATTTGTAGAAATGCATAAAATAAAAAGACCAGGGTGCTACCAACACCCC
AGCTCTGTACAAAAAGCTGCCCATCAAAGGGCTTGCTCAGATGTATGTGACATAGTAGACCAACCCTTTAGGGTCGCAAT
CTCAAGGGGAGGTCTATTT

Structures

Toxin

• AlphaFold DB: A0A7Z7EVU9

Antitoxin